Is the “probable” category required in the diagnosis of ABPA?

Interestingly, we have also recently evaluated the existing criteria and proposed certain modifications using latent class analysis.2 Although there are several common features to the modified ISHAM criteria and the criteria by Asano et al, there are key differences. A few of these 20 cases might have been classified as ABPA by the other criteria if any of the dynamic immunologic parameters (eosinophil count or total IgE) was elevated, whereas some of them (n = 9 [45%]) were misclassification because they lacked allergic sensitization to A fumigatus (A fumigatus IgE < 0.35, and a negative Aspergillus skin test result). Age (y) Sex AST Total IgE A fumigatus IgE A fumigatus IgG TEC Sputum fungus CB HAM Mucoid impaction First MDT diagnosis Second MDT diagnosis 1 46 Male Negative 861 28.5 26 200 Negative Present Absent Present Bronchiectasis with Aspergillus sensitization Inactive ABPA 2 53 Female Negative 92 0.02 121 450 Negative Present Absent Present Bronchiectasis with Aspergillus infection — 3 37 Female Positive 452 0.03 35.6 510 Negative Absent Absent Absent Asthma with fungal sensitization — 4 25 Male Negative 407 0.03 45.1 590 A fumigatus Present Absent Present Bronchiectasis with Aspergillus infection — 5 39 Female Positive 252 80 78.8 510 Negative Present Absent Absent Inactive ABPA — 6 52 Female Negative 551 0.07 39.3 100 Negative Present Absent Absent Bronchiectasis with Aspergillus infection — 7 31 Male Positive 632 17.1 22 90 Negative Present Absent Absent Bronchiectasis with Aspergillus sensitization Inactive ABPA 8 26 Male Negative 212 4.26 25.9 300 A fumigatus Present Absent Present Bronchiectasis with Aspergillus sensitization Inactive ABPA 9 38 Male Positive 612 19.4 26.4 420 Negative Present Absent Present Bronchiectasis with Aspergillus sensitization Inactive ABPA 10 30 Female Positive 611 0.15 32 500 Negative Present Absent Absent Bronchiectasis with Aspergillus infection — 11 19 Female Negative 832 0.04 11 500 A fumigatus Present Absent Absent Bronchiectasis with Aspergillus colonization — 12 37 Male Positive 545 0.08 200 560 Negative Absent Absent Absent Asthma with fungal sensitization — 13 27 Male Positive 811 0.07 200 580 Negative Absent Absent Absent Asthma with fungal sensitization — 14 24 Male Negative 718 0.27 3.84 900 A fumigatus Absent Absent Absent Asthma with Aspergillus colonization — 15 24 Male Negative 193 1.55 99.9 600 Negative Absent Absent Absent Asthma with fungal sensitization — 16 40 Female Positive 170 8.36 45.2 500