A single-center retrospective analysis of outcome measures and consolidation strategies for relapsed and refractory primary CNS lymphoma

A single-center retrospective analysis of outcome measures and consolidation strategies for relapsed and refractory primary CNS lymphoma

Background Relapsed or refractory primary CNS lymphoma (rrPCNSL) is a rare and challenging malignancy for which better evidence is needed to guide management. Methods We present a retrospective cohort of 66 consecutive patients with rrPCNSL treated at the University of Washington between 2000 and 20...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neuro-oncology 2021, Vol.151 (2), p.193-200
Hauptverfasser: Bonm, Alipi V., Gibson, Alec W., Holmberg, Leona A., Mielcarek, Marco, McGranahan, Tresa, Taylor, Lynne P., Graber, Jerome J.
Format: Artikel
Sprache:eng
Schlagworte:
Autografts
Clinical Study
Diagnosis
Lymphoma
Malignancy
Medicine
Medicine & Public Health
Methotrexate
Multivariate analysis
Neurology
Oncology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background Relapsed or refractory primary CNS lymphoma (rrPCNSL) is a rare and challenging malignancy for which better evidence is needed to guide management. Methods We present a retrospective cohort of 66 consecutive patients with rrPCNSL treated at the University of Washington between 2000 and 2020. Immunosuppressed and secondary CNS lymphoma patients were excluded. Results During a median follow-up of 40.5 months from initial diagnosis, median OS for relapsed disease was 14.1 (0.2–88.5) months and median PFS was 11.0 (0.2–73.9) months. At diagnosis (r 2  = 0.85, p 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-020-03648-9