MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2021-02, Vol.99 (2), p.289-301
Hauptverfasser:	Kinker, G. S., Ostrowski, L. H., Ribeiro, P. A. C., Chanoch, R., Muxel, S. M., Tirosh, I., Spadoni, G., Rivara, S., Martins, V. R., Santos, T. G., Markus, R. P., Fernandes, P. A. C. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain - metabolism Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - pathology Brain tumors Cell activation Cell cycle Cell Line, Tumor Cell Proliferation Disease Progression Energy metabolism Female Gene expression Glioblastoma Glioma Glioma - genetics Glioma - metabolism Glioma - mortality Glioma - pathology Glioma cells Human Genetics Humans Internal Medicine Kaplan-Meier Estimate Male Malignancy Medulloblastoma Melatonin Melatonin receptors Metabolism Mice Mice, Inbred BALB C Mice, Nude Microenvironments Molecular Medicine Original Article Receptor, Melatonin, MT1 - genetics Receptor, Melatonin, MT1 - metabolism Receptor, Melatonin, MT2 - genetics Receptor, Melatonin, MT2 - metabolism Tumors
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Beschreibung
Zusammenfassung:	Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
ISSN:	0946-2716 1432-1440
DOI:	10.1007/s00109-020-02023-5