Production of Optically Active Hexahydrocurcumin by Human Intestinal Bacterium in Vitro

Production of Optically Active Hexahydrocurcumin by Human Intestinal Bacterium in Vitro

A hexahydrocurcumin-producing bacterium named 2a1-2b was isolated from human feces. It was observed that the bacterium had more than 99% similarity with Enterococcus avium ATCC14025T according to 16S ribosomal DNA (rDNA) sequence. The strain 2a1-2b produced optically active 5R-hexahydrocurcumin (ena...

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Veröffentlicht in:Biological & pharmaceutical bulletin 2021/01/01, Vol.44(1), pp.136-139
Hauptverfasser: Niwa, Toshio, Yokoyama, Shin-ichiro, Mochizuki, Mika, Osawa, Toshihiko
Format: Artikel
Sprache:eng
Schlagworte:
Curcumin
hexahydrocurcumin
Intestine
microflora
Nucleotide sequence
optical activity
Ribosomal DNA
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Zusammenfassung:A hexahydrocurcumin-producing bacterium named 2a1-2b was isolated from human feces. It was observed that the bacterium had more than 99% similarity with Enterococcus avium ATCC14025T according to 16S ribosomal DNA (rDNA) sequence. The strain 2a1-2b produced optically active 5R-hexahydrocurcumin (enantiomeric excess (e.e.) > 95%) from tetrahydrocurcumin but not from curcumin. Our results showed that intestine is an important place for producing hexahydrocurcumin.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b20-00584