Decline in eGFR over time and incidence of cardiovascular events: Shinken database analysis

•Incidence of cardiovascular events was more frequent in low estimated glomerular filtration rate (eGFR) than high eGFR group.•A large decline in eGFR was more observed in high eGFR than low eGFR group.•A large decline in eGFR was at a 2-fold risk of cardiovascular events. It has been reported that a large decline in estimated glomerular filtration rate (eGFR) over time is associated with increased incidence of cardiovascular disease. We investigated whether this association differs according to the baseline eGFR. A total of 4666 patients (male 71%) with measurements of eGFR at both baseline and 1 year and that had no cardiovascular events at 1-year follow-up were retrieved from the Shinken Database between June 2004 and March 2015. The study population was divided into three groups by baseline eGFR (mL/min/1.73 m2): high (≥60, n = 1650), intermediate (45–59, n = 1947), and low (