How to diSARM the executioner of axon degeneration
The protein SARM1 is an executioner of axon degeneration through its NAD + hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD + as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD + levels and c...
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| Veröffentlicht in: | Nature structural & molecular biology 2021-01, Vol.28 (1), p.10-12 |
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| container_title | Nature structural & molecular biology |
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| creator | Tong, Liang |
| description | The protein SARM1 is an executioner of axon degeneration through its NAD
+
hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD
+
as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD
+
levels and causes NAD
+
collapse and axon degeneration. |
| doi_str_mv | 10.1038/s41594-020-00545-7 |
| format | Article |
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+
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+
as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD
+
levels and causes NAD
+
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+
hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD
+
as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD
+
levels and causes NAD
+
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| subjects | 631/45 631/45/173 631/535/1258/1259 Allosteric properties Animals Armadillo Domain Proteins - metabolism Asymmetry Axons - pathology Biochemistry Biological Microscopy Biomedical and Life Sciences Biosynthesis Cell receptors Cytoskeletal Proteins - metabolism Degeneration Genetic aspects Health aspects Humans Hydrolase Life Sciences Lipids Membrane Biology Molecular biology NAD NAD (Coenzyme) NAD - metabolism NAD+ Nucleosidase - metabolism Nerve Degeneration - pathology Nervous system News & Views news-and-views Protein Domains - physiology Protein Structure Structure |
| title | How to diSARM the executioner of axon degeneration |
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