How to diSARM the executioner of axon degeneration

The protein SARM1 is an executioner of axon degeneration through its NAD + hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD + as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD + levels and c...

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Veröffentlicht in:	Nature structural & molecular biology 2021-01, Vol.28 (1), p.10-12
1. Verfasser:	Tong, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/45/173 631/535/1258/1259 Allosteric properties Animals Armadillo Domain Proteins - metabolism Asymmetry Axons - pathology Biochemistry Biological Microscopy Biomedical and Life Sciences Biosynthesis Cell receptors Cytoskeletal Proteins - metabolism Degeneration Genetic aspects Health aspects Humans Hydrolase Life Sciences Lipids Membrane Biology Molecular biology NAD NAD (Coenzyme) NAD - metabolism NAD+ Nucleosidase - metabolism Nerve Degeneration - pathology Nervous system News & Views news-and-views Protein Domains - physiology Protein Structure Structure
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Beschreibung
Zusammenfassung:	The protein SARM1 is an executioner of axon degeneration through its NAD + hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD + as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD + levels and causes NAD + collapse and axon degeneration.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-020-00545-7