Sc(OTf) 3 -catalyzed [3 + 2]-cycloaddition of nitrones with ynones

Sc(OTf) 3 -catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functional...

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Veröffentlicht in:Organic & biomolecular chemistry 2021-01, Vol.19 (2), p.457-466
Hauptverfasser: He, Chun-Ting, Han, Xiao-Li, Zhang, Yan-Xue, Du, Zhen-Ting, Si, Chang-Mei, Wei, Bang-Guo
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography
Cycloaddition
Ketones
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Zusammenfassung:An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob02158j