Glucose Tolerance Stages in Cystic Fibrosis Are Identified by a Unique Pattern of Defects of Beta-Cell Function

Glucose Tolerance Stages in Cystic Fibrosis Are Identified by a Unique Pattern of Defects of Beta-Cell Function

Abstract Objective We aimed to assess the order of severity of the defects of 3 direct determinants of glucose regulation—beta-cell function, insulin clearance, and insulin sensitivity—in patients with cystic fibrosis (CF), categorized according their glucose tolerance status, including early elevat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The journal of clinical endocrinology and metabolism 2021-04, Vol.106 (4), p.e1793-e1802
Hauptverfasser: Piona, Claudia, Volpi, Sonia, Zusi, Chiara, Mozzillo, Enza, Tosco, Antonella, Franzese, Adriana, Raia, Valeria, Boselli, Maria Linda, Trombetta, Maddalena, Cipolli, Marco, Bonadonna, Riccardo C, Maffeis, Claudio
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Beta cells
Cystic fibrosis
Dextrose
Diabetes mellitus
Glucose
Glucose metabolism
Glucose tolerance
Glucose tolerance tests
Insulin
Insulin secretion
Mathematical models
Pancreatic beta cells
Physiological aspects
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Objective We aimed to assess the order of severity of the defects of 3 direct determinants of glucose regulation—beta-cell function, insulin clearance, and insulin sensitivity—in patients with cystic fibrosis (CF), categorized according their glucose tolerance status, including early elevation of mid-level oral glucose tolerance test (OGTT) glucose values (>140 and
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgaa932