Artificial intelligence applications for oncological positron emission tomography imaging

•Quantitative and objective features of medical images have been explored to recognize reliable biomarkers, with the development of PET radiomics.•We should take all cautions into consideration before using the techniques based on PET radiomics.•Radiomics alone is inadequate which should be verified by gene sequencing data, histological reference, or molecular mechanisms. Positron emission tomography (PET), a functional and dynamic molecular imaging technique, is generally used to reveal tumors’ biological behavior. Radiomics allows a high-throughput extraction of multiple features from images with artificial intelligence (AI) approaches and develops rapidly worldwide. Quantitative and objective features of medical images have been explored to recognize reliable biomarkers, with the development of PET radiomics. This paper will review the current clinical exploration of PET-based classical machine learning and deep learning methods, including disease diagnosis, the prediction of histological subtype, gene mutation status, tumor metastasis, tumor relapse, therapeutic side effects, therapeutic intervention and evaluation of prognosis. The applications of AI in oncology will be mainly discussed. The image-guided biopsy or surgery assisted by PET-based AI will be introduced as well. This paper aims to present the applications and methods of AI for PET imaging, which may offer important details for further clinical studies. Relevant precautions are put forward and future research directions are suggested.