Dynamic Impact of Hormone Therapy on Laboratory Values in Transgender Patients over Time

Known physiological changes occur while transgender patients are taking hormone therapy (HT). However, knowledge is limited about when laboratory values stabilize and if there are any long-term impacts, making it challenging for physicians to provide adequate gender-affirming care. We aim to analyze...

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Veröffentlicht in:The journal of applied laboratory medicine 2021-01, Vol.6 (1), p.27-40
Hauptverfasser: Allen, Amber N, Jiao, Rhoda, Day, Philip, Pagels, Patti, Gimpel, Nora, SoRelle, Jeffrey A
Format: Artikel
Sprache:eng
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Zusammenfassung:Known physiological changes occur while transgender patients are taking hormone therapy (HT). However, knowledge is limited about when laboratory values stabilize and if there are any long-term impacts, making it challenging for physicians to provide adequate gender-affirming care. We aim to analyze laboratory values with HT use over 5 years and after discontinuation of HT to define when values achieve stability. We performed a multicenter retrospective analysis of 126 transgender women (TW) and 91 transgender men (TM) at consecutive clinic visits. Labs included complete metabolic panel, complete blood count, lipids, and hormone levels and were monitored for 5 years. Absolute measurement and percentage change from baseline were calculated for each analyte value. We collected the laboratory studies described from patients off HT and the duration of discontinuation to determine the time to return to baseline levels. During HT, red blood cell (RBC; erythrocyte) indexes reach stable levels within 6 months (P 
ISSN:2576-9456
2475-7241
DOI:10.1093/jalm/jfaa192