Catalytic Ynone–Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines

Catalytic Ynone–Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines

A Ca­(OTf)2- and self-promoted ynone–amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the...

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Veröffentlicht in:Organic letters 2020-12, Vol.22 (24), p.9653-9657
Hauptverfasser: Reddy, T. Prabhakar, Gujral, Jagjeet, Roy, Pritam, Ramachary, Dhevalapally B
Format: Artikel
Sprache:eng
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Zusammenfassung:A Ca­(OTf)2- and self-promoted ynone–amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03711