Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database
•Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact of MS on fertility•Women with MS had lower live birth rates than those without MS•Women with MS were less likely to receive oral or injectable infertility...
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| Veröffentlicht in: | Multiple sclerosis and related disorders 2020-11, Vol.46, p.102541-102541, Article 102541 |
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| container_title | Multiple sclerosis and related disorders |
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| creator | Houtchens, Maria K. Edwards, Natalie C. Hayward, Brooke Mahony, Mary C. Phillips, Amy L. |
| description | •Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact of MS on fertility•Women with MS had lower live birth rates than those without MS•Women with MS were less likely to receive oral or injectable infertility treatment•Live birth rates following infertility treatment were similar irrespective of MS
Real-world data regarding live birth rates (LBRs) and infertility in women with multiple sclerosis (MS) are lacking. This study compared LBRs, infertility diagnoses, and infertility treatments in women with and without MS.
Using a retrospective US administrative claims database, patients 18–55 years with MS were matched 1:1 to patients without MS to compare LBRs, infertility diagnoses, and infertility treatments used between cohorts.
Overall LBRs were lower in women with MS (n=96,937) versus women without (n=96,937; 5.0% vs 7.0%; p |
| doi_str_mv | 10.1016/j.msard.2020.102541 |
| format | Article |
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Real-world data regarding live birth rates (LBRs) and infertility in women with multiple sclerosis (MS) are lacking. This study compared LBRs, infertility diagnoses, and infertility treatments in women with and without MS.
Using a retrospective US administrative claims database, patients 18–55 years with MS were matched 1:1 to patients without MS to compare LBRs, infertility diagnoses, and infertility treatments used between cohorts.
Overall LBRs were lower in women with MS (n=96,937) versus women without (n=96,937; 5.0% vs 7.0%; p<0.0001). A greater proportion of women with MS than without had a diagnosis of infertility (8.5% vs 8.1%; p=0.0006). Fewer women with MS than without used any infertility treatment (1.0% vs 1.2%; p=0.0002). Among women with or without MS who received infertility treatments, no significant difference was observed in LBRs with oral (32.2% vs 31.5%; p=0.8536) or injectable (44.0% vs 49.3%; p=0.2603) treatment.
Women with MS had a lower LBR, received more infertility diagnoses, and were less likely to receive infertility treatment than women without MS. There was no difference in LBRs following infertility treatment. Claims-data studies provide valuable exploratory analyses that reflect interactions between patients and the healthcare system.</description><identifier>ISSN: 2211-0348</identifier><identifier>EISSN: 2211-0356</identifier><identifier>DOI: 10.1016/j.msard.2020.102541</identifier><identifier>PMID: 33296964</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>administrative claims, live birth rate ; Birth Rate ; Delivery of Health Care ; Female ; Humans ; Infertility ; infertility treatment ; multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - epidemiology ; Retrospective Studies</subject><ispartof>Multiple sclerosis and related disorders, 2020-11, Vol.46, p.102541-102541, Article 102541</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-a0215b5f4240f3362ef51942b810b4da1f9d8f14e0dab03668aaf4fdc00e76e53</citedby><cites>FETCH-LOGICAL-c404t-a0215b5f4240f3362ef51942b810b4da1f9d8f14e0dab03668aaf4fdc00e76e53</cites><orcidid>0000-0001-6077-0654 ; 0000-0002-1234-7445</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33296964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houtchens, Maria K.</creatorcontrib><creatorcontrib>Edwards, Natalie C.</creatorcontrib><creatorcontrib>Hayward, Brooke</creatorcontrib><creatorcontrib>Mahony, Mary C.</creatorcontrib><creatorcontrib>Phillips, Amy L.</creatorcontrib><title>Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database</title><title>Multiple sclerosis and related disorders</title><addtitle>Mult Scler Relat Disord</addtitle><description>•Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact of MS on fertility•Women with MS had lower live birth rates than those without MS•Women with MS were less likely to receive oral or injectable infertility treatment•Live birth rates following infertility treatment were similar irrespective of MS
Real-world data regarding live birth rates (LBRs) and infertility in women with multiple sclerosis (MS) are lacking. This study compared LBRs, infertility diagnoses, and infertility treatments in women with and without MS.
Using a retrospective US administrative claims database, patients 18–55 years with MS were matched 1:1 to patients without MS to compare LBRs, infertility diagnoses, and infertility treatments used between cohorts.
Overall LBRs were lower in women with MS (n=96,937) versus women without (n=96,937; 5.0% vs 7.0%; p<0.0001). A greater proportion of women with MS than without had a diagnosis of infertility (8.5% vs 8.1%; p=0.0006). Fewer women with MS than without used any infertility treatment (1.0% vs 1.2%; p=0.0002). Among women with or without MS who received infertility treatments, no significant difference was observed in LBRs with oral (32.2% vs 31.5%; p=0.8536) or injectable (44.0% vs 49.3%; p=0.2603) treatment.
Women with MS had a lower LBR, received more infertility diagnoses, and were less likely to receive infertility treatment than women without MS. There was no difference in LBRs following infertility treatment. Claims-data studies provide valuable exploratory analyses that reflect interactions between patients and the healthcare system.</description><subject>administrative claims, live birth rate</subject><subject>Birth Rate</subject><subject>Delivery of Health Care</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility</subject><subject>infertility treatment</subject><subject>multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Retrospective Studies</subject><issn>2211-0348</issn><issn>2211-0356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EolXpEyAhHzmwi-04JkHigMq_Sitxac_WxB7DrOJksZ1WfRceFoctlbjUF4_Gv_lmxh9jL6XYSiHN2_02Zkh-q4RaM6rV8gk7VUrKjWha8_Qh1t0JO895L-oxrdRGPmcnTaN60xt9yn7v6Ab5QKn85AkK5jecpoCp0EjljnuCH9OcqaZh8v89lYRQIk6lZvntXCN-S1Vl5dZgXgqPy1joMCLPbsS06rznn6AAD2mOleTgI02US229zuFGoJi5r8gAGV-wZwHGjOf39xm7_vL56uLbZvf96-XFx93GaaHLBoSS7dAGrbQITWMUhlb2Wg2dFIP2IEPvuyA1Cg-DaIzpAIIO3gmB7wy2zRl7fdQ9pPnXgrnYSNnhOMKE85Kt0qYXXf2wvqLNEXV1nZww2EOiCOnOSmFXZ-ze_nXGrs7YozO16tV9g2WI6B9q_vlQgQ9HAOuaN4TJZkc4OfSU0BXrZ3q0wR9boaNy</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Houtchens, Maria K.</creator><creator>Edwards, Natalie C.</creator><creator>Hayward, Brooke</creator><creator>Mahony, Mary C.</creator><creator>Phillips, Amy L.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6077-0654</orcidid><orcidid>https://orcid.org/0000-0002-1234-7445</orcidid></search><sort><creationdate>202011</creationdate><title>Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database</title><author>Houtchens, Maria K. ; Edwards, Natalie C. ; Hayward, Brooke ; Mahony, Mary C. ; Phillips, Amy L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-a0215b5f4240f3362ef51942b810b4da1f9d8f14e0dab03668aaf4fdc00e76e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>administrative claims, live birth rate</topic><topic>Birth Rate</topic><topic>Delivery of Health Care</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility</topic><topic>infertility treatment</topic><topic>multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Retrospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Houtchens, Maria K.</creatorcontrib><creatorcontrib>Edwards, Natalie C.</creatorcontrib><creatorcontrib>Hayward, Brooke</creatorcontrib><creatorcontrib>Mahony, Mary C.</creatorcontrib><creatorcontrib>Phillips, Amy L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis and related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houtchens, Maria K.</au><au>Edwards, Natalie C.</au><au>Hayward, Brooke</au><au>Mahony, Mary C.</au><au>Phillips, Amy L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database</atitle><jtitle>Multiple sclerosis and related disorders</jtitle><addtitle>Mult Scler Relat Disord</addtitle><date>2020-11</date><risdate>2020</risdate><volume>46</volume><spage>102541</spage><epage>102541</epage><pages>102541-102541</pages><artnum>102541</artnum><issn>2211-0348</issn><eissn>2211-0356</eissn><abstract>•Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact of MS on fertility•Women with MS had lower live birth rates than those without MS•Women with MS were less likely to receive oral or injectable infertility treatment•Live birth rates following infertility treatment were similar irrespective of MS
Real-world data regarding live birth rates (LBRs) and infertility in women with multiple sclerosis (MS) are lacking. This study compared LBRs, infertility diagnoses, and infertility treatments in women with and without MS.
Using a retrospective US administrative claims database, patients 18–55 years with MS were matched 1:1 to patients without MS to compare LBRs, infertility diagnoses, and infertility treatments used between cohorts.
Overall LBRs were lower in women with MS (n=96,937) versus women without (n=96,937; 5.0% vs 7.0%; p<0.0001). A greater proportion of women with MS than without had a diagnosis of infertility (8.5% vs 8.1%; p=0.0006). Fewer women with MS than without used any infertility treatment (1.0% vs 1.2%; p=0.0002). Among women with or without MS who received infertility treatments, no significant difference was observed in LBRs with oral (32.2% vs 31.5%; p=0.8536) or injectable (44.0% vs 49.3%; p=0.2603) treatment.
Women with MS had a lower LBR, received more infertility diagnoses, and were less likely to receive infertility treatment than women without MS. There was no difference in LBRs following infertility treatment. Claims-data studies provide valuable exploratory analyses that reflect interactions between patients and the healthcare system.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33296964</pmid><doi>10.1016/j.msard.2020.102541</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6077-0654</orcidid><orcidid>https://orcid.org/0000-0002-1234-7445</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | administrative claims, live birth rate Birth Rate Delivery of Health Care Female Humans Infertility infertility treatment multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Multiple Sclerosis - epidemiology Retrospective Studies |
| title | Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database |
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