Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database

•Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact of MS on fertility•Women with MS had lower live birth rates than those without MS•Women with MS were less likely to receive oral or injectable infertility treatment•Live birth rates following infertility treatment were similar irrespective of MS Real-world data regarding live birth rates (LBRs) and infertility in women with multiple sclerosis (MS) are lacking. This study compared LBRs, infertility diagnoses, and infertility treatments in women with and without MS. Using a retrospective US administrative claims database, patients 18–55 years with MS were matched 1:1 to patients without MS to compare LBRs, infertility diagnoses, and infertility treatments used between cohorts. Overall LBRs were lower in women with MS (n=96,937) versus women without (n=96,937; 5.0% vs 7.0%; p