Geomagnetic Shielding Enhances Radiation Resistance by Promoting DNA Repair Process in Human Bronchial Epithelial Cells

With the advent of long-duration space explorations, ionizing radiation (IR) may pose a constant threat to astronauts without the protection of Earth's magnetic field, or hypomagnetic field (HMF). However, the potential biological effects of a HMF on the cellular response to IR have not been we...

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Veröffentlicht in:	International journal of molecular sciences 2020-12, Vol.21 (23), p.9304, Article 9304
Hauptverfasser:	Xue, Xunwen, Ali, Yasser F., Liu, Caorui, Hong, Zhiqiang, Luo, Wanrong, Nie, Jing, Li, Bingyan, Jiao, Yang, Liu, Ning-Ang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Astronauts Biochemistry & Molecular Biology Biological effects Brief Report Bronchi - cytology Cell culture Cell cycle Cell Line Chemistry Chemistry, Multidisciplinary Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA damage response DNA Repair Earth Epithelial cells Epithelial Cells - metabolism Epithelial Cells - radiation effects Genotoxicity Geomagnetic field Geomagnetism Histones - metabolism human lung epithelial cells Humans hypomagnetic field Ionizing radiation Life Sciences & Biomedicine Magnetic Fields Magnetic shielding Physical Sciences Radiation shielding Radiation Tolerance Radiation, Ionizing Repair Science & Technology
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Zusammenfassung:	With the advent of long-duration space explorations, ionizing radiation (IR) may pose a constant threat to astronauts without the protection of Earth's magnetic field, or hypomagnetic field (HMF). However, the potential biological effects of a HMF on the cellular response to IR have not been well characterized so far. In this study, immortalized human bronchial epithelial cells were exposed to X-rays under either a geomagnetic field (GMF, similar to 50 uT) or HMF (
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms21239304