Risk factors for the development of high‐grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas: Large retrospective cohort study

Risk factors for the development of high‐grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas: Large retrospective cohort study

Background The incidence and risk factors for the development of high‐grade dysplasia (HG‐D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP). Methods Clinical data, human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybrid...

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Veröffentlicht in:Head & neck 2021-03, Vol.43 (3), p.956-966
Hauptverfasser: Gluvajić, Daša, Hošnjak, Lea, Stegel, Vida, Novaković, Srdjan, Gale, Nina, Poljak, Mario, Boltežar, Irena Hočevar
Format: Artikel
Sprache:eng
Schlagworte:
carcinoma
Cohort analysis
Dysplasia
Head and neck
human papilloma virus
Human papillomavirus
Hybridization
Laryngeal cancer
larynx
mRNA
Mutation
papilloma
Papillomaviridae
Risk factors
Squamous cell carcinoma
Typing
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Zusammenfassung:Background The incidence and risk factors for the development of high‐grade dysplasia (HG‐D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP). Methods Clinical data, human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybridization, and sequencing of host genes in LSP biopsies of 163 patients were analyzed. Results Progression to HG‐D and LSCC was identified in 21.5% and 4.3% of LSP patients, respectively. A more advanced age at LSP onset and lack of HPV infection were detected as risk factors for the development of HG‐D and LSCC (P
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26560