The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases
[Display omitted] •A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS t...
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| Veröffentlicht in: | Carbohydrate polymers 2021-02, Vol.253, p.117246-117246, Article 117246 |
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| container_title | Carbohydrate polymers |
| container_volume | 253 |
| creator | Anraku, Makoto Mizukai, Yasuyuki Maezaki, Yuji Kawano, Kazuo Okazaki, Shoko Takeshita, Keizo Adachi, Tomoki Otagiri, Masaki Iohara, Daisuke Hirayama, Fumitoshi |
| description | [Display omitted]
•A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS tablets than to N-CS tablets.•G-CS tablets are useful as a rapidly disintegrating carrier and as an oral adsorbent.
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tablets in vivo was confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases. |
| doi_str_mv | 10.1016/j.carbpol.2020.117246 |
| format | Article |
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•A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS tablets than to N-CS tablets.•G-CS tablets are useful as a rapidly disintegrating carrier and as an oral adsorbent.
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tablets in vivo was confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2020.117246</identifier><identifier>PMID: 33279001</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Oral ; Adsorption ; Animals ; Chitosan ; Chitosan - administration & dosage ; Chitosan - chemistry ; Chitosan - metabolism ; Chronic Disease - drug therapy ; Crystallization ; Disintegration ; Dispersion ; Drug Carriers - chemistry ; Gastrointestinal Tract - diagnostic imaging ; Gastrointestinal Tract - metabolism ; Life Style ; Magnetic Resonance Imaging ; Male ; Powders - chemistry ; Rats ; Rats, Wistar ; Release property ; Sorption Detoxification - methods ; Tablets - administration & dosage ; Tablets - chemistry ; Tablets - metabolism ; Temperature ; Water - chemistry ; Wet granulation</subject><ispartof>Carbohydrate polymers, 2021-02, Vol.253, p.117246-117246, Article 117246</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-aea2736dedb072595c539bc4dbc70cf247f787653824235cf7eaee6bfd12e9353</citedby><cites>FETCH-LOGICAL-c365t-aea2736dedb072595c539bc4dbc70cf247f787653824235cf7eaee6bfd12e9353</cites><orcidid>0000-0001-8249-6983 ; 0000-0002-7071-0628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2020.117246$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33279001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anraku, Makoto</creatorcontrib><creatorcontrib>Mizukai, Yasuyuki</creatorcontrib><creatorcontrib>Maezaki, Yuji</creatorcontrib><creatorcontrib>Kawano, Kazuo</creatorcontrib><creatorcontrib>Okazaki, Shoko</creatorcontrib><creatorcontrib>Takeshita, Keizo</creatorcontrib><creatorcontrib>Adachi, Tomoki</creatorcontrib><creatorcontrib>Otagiri, Masaki</creatorcontrib><creatorcontrib>Iohara, Daisuke</creatorcontrib><creatorcontrib>Hirayama, Fumitoshi</creatorcontrib><title>The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>[Display omitted]
•A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS tablets than to N-CS tablets.•G-CS tablets are useful as a rapidly disintegrating carrier and as an oral adsorbent.
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tablets in vivo was confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases.</description><subject>Administration, Oral</subject><subject>Adsorption</subject><subject>Animals</subject><subject>Chitosan</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - metabolism</subject><subject>Chronic Disease - drug therapy</subject><subject>Crystallization</subject><subject>Disintegration</subject><subject>Dispersion</subject><subject>Drug Carriers - chemistry</subject><subject>Gastrointestinal Tract - diagnostic imaging</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Life Style</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Powders - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Release property</subject><subject>Sorption Detoxification - methods</subject><subject>Tablets - administration & dosage</subject><subject>Tablets - chemistry</subject><subject>Tablets - metabolism</subject><subject>Temperature</subject><subject>Water - chemistry</subject><subject>Wet granulation</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuO0zAUtRCIKYVPAHnJJsWvxMkKodHwkEZiM6ytG_uGunLjYLsj9WP4V9xJYYs31j06j2sfQt5ytuOMdx8OOwtpXGLYCSYqxrVQ3TOy4b0eGi6Vek42jCvV9B3XN-RVzgdWT8fZS3IjpdADY3xDfj_skS4JF0hQfJwpzI4-QvBuHeNE7d6XmGGmBcaAJdOyh0ITLN6FM3U-L5gyPgnr4OeCP6tXBXLFaEwQKLgc04hzob7a1MSSEMrxAtSA4CfM5RywSRiq8skHIWN-TV5MEDK-ud5b8uPz3cPt1-b--5dvt5_uGyu7tjSAILTsHLqRadEOrW3lMFrlRquZnYTSk-5118peKCFbO2kExG6cHBc4yFZuyfvVd0nx16kuY44-WwwBZoynbOrX6l51bVVvSbtSbYo5J5zMkvwR0tlwZi7NmIO5NmMuzZi1map7d404jUd0_1R_q6iEjysB60MfPSaTrcfZovMJbTEu-v9E_AGFTKXn</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Anraku, Makoto</creator><creator>Mizukai, Yasuyuki</creator><creator>Maezaki, Yuji</creator><creator>Kawano, Kazuo</creator><creator>Okazaki, Shoko</creator><creator>Takeshita, Keizo</creator><creator>Adachi, Tomoki</creator><creator>Otagiri, Masaki</creator><creator>Iohara, Daisuke</creator><creator>Hirayama, Fumitoshi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8249-6983</orcidid><orcidid>https://orcid.org/0000-0002-7071-0628</orcidid></search><sort><creationdate>20210201</creationdate><title>The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases</title><author>Anraku, Makoto ; Mizukai, Yasuyuki ; Maezaki, Yuji ; Kawano, Kazuo ; Okazaki, Shoko ; Takeshita, Keizo ; Adachi, Tomoki ; Otagiri, Masaki ; Iohara, Daisuke ; Hirayama, Fumitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-aea2736dedb072595c539bc4dbc70cf247f787653824235cf7eaee6bfd12e9353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Administration, Oral</topic><topic>Adsorption</topic><topic>Animals</topic><topic>Chitosan</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - metabolism</topic><topic>Chronic Disease - drug therapy</topic><topic>Crystallization</topic><topic>Disintegration</topic><topic>Dispersion</topic><topic>Drug Carriers - chemistry</topic><topic>Gastrointestinal Tract - diagnostic imaging</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Life Style</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Powders - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Release property</topic><topic>Sorption Detoxification - methods</topic><topic>Tablets - administration & dosage</topic><topic>Tablets - chemistry</topic><topic>Tablets - metabolism</topic><topic>Temperature</topic><topic>Water - chemistry</topic><topic>Wet granulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anraku, Makoto</creatorcontrib><creatorcontrib>Mizukai, Yasuyuki</creatorcontrib><creatorcontrib>Maezaki, Yuji</creatorcontrib><creatorcontrib>Kawano, Kazuo</creatorcontrib><creatorcontrib>Okazaki, Shoko</creatorcontrib><creatorcontrib>Takeshita, Keizo</creatorcontrib><creatorcontrib>Adachi, Tomoki</creatorcontrib><creatorcontrib>Otagiri, Masaki</creatorcontrib><creatorcontrib>Iohara, Daisuke</creatorcontrib><creatorcontrib>Hirayama, Fumitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anraku, Makoto</au><au>Mizukai, Yasuyuki</au><au>Maezaki, Yuji</au><au>Kawano, Kazuo</au><au>Okazaki, Shoko</au><au>Takeshita, Keizo</au><au>Adachi, Tomoki</au><au>Otagiri, Masaki</au><au>Iohara, Daisuke</au><au>Hirayama, Fumitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>253</volume><spage>117246</spage><epage>117246</epage><pages>117246-117246</pages><artnum>117246</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>[Display omitted]
•A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS tablets than to N-CS tablets.•G-CS tablets are useful as a rapidly disintegrating carrier and as an oral adsorbent.
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tablets in vivo was confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33279001</pmid><doi>10.1016/j.carbpol.2020.117246</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8249-6983</orcidid><orcidid>https://orcid.org/0000-0002-7071-0628</orcidid></addata></record> |
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| ispartof | Carbohydrate polymers, 2021-02, Vol.253, p.117246-117246, Article 117246 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2467846542 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Oral Adsorption Animals Chitosan Chitosan - administration & dosage Chitosan - chemistry Chitosan - metabolism Chronic Disease - drug therapy Crystallization Disintegration Dispersion Drug Carriers - chemistry Gastrointestinal Tract - diagnostic imaging Gastrointestinal Tract - metabolism Life Style Magnetic Resonance Imaging Male Powders - chemistry Rats Rats, Wistar Release property Sorption Detoxification - methods Tablets - administration & dosage Tablets - chemistry Tablets - metabolism Temperature Water - chemistry Wet granulation |
| title | The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases |
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