The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases
[Display omitted] •A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS t...
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Veröffentlicht in: | Carbohydrate polymers 2021-02, Vol.253, p.117246-117246, Article 117246 |
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Format: | Artikel |
Sprache: | eng |
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•A tablet was prepared from granulated chitosan (G-CS) particles.•G-CS tablets was highly dispersible and disintegrated rapidly in aqueous media.•The rapid disintegration and dispersion of G-CS tablets in vivo was confirmed by MRI.•Ureic toxins were adsorbed more strongly to G-CS tablets than to N-CS tablets.•G-CS tablets are useful as a rapidly disintegrating carrier and as an oral adsorbent.
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tablets in vivo was confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases. |
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ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2020.117246 |