Paradoxical effect of SARS‐CoV‐2 infection in patients with immune thrombocytopenia

Summary Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID‐19) in patients with immune thrombocytopenia (ITP), a re...

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Veröffentlicht in:	British journal of haematology 2021-03, Vol.192 (6), p.973-977
Hauptverfasser:	Cruz‐Benito, Beatriz, Rivas‐Pollmar, María I., Álvarez Román, María T., Trelles‐Martínez, Roberto, Martín‐Salces, Monica, Lázaro‐del Campo, Paula, Ramírez‐López, Andrés, García‐Barcenilla, Sara, Cebanu, Tamara, Acuña‐Butta, Paula, Monzón‐Manzano, Elena, González‐Zorrilla, Elena, Jiménez‐Yuste, Victor, Butta, Nora V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Chronic infection Coronaviridae Coronaviruses COVID-19 COVID-19 - blood COVID-19 - pathology COVID-19 - virology Female Hematology Humans Idiopathic thrombocytopenic purpura immune thrombocytopenia Infections Lymphopenia Male Middle Aged Retrospective Studies SARS-CoV-2 - isolation & purification SARS‐CoV‐2 Severe acute respiratory syndrome coronavirus 2 Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - immunology Thrombocytopenia - pathology Thrombocytopenia - virology Thrombocytosis
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Zusammenfassung:	Summary Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID‐19) in patients with immune thrombocytopenia (ITP), a retrospective single‐centre study was performed. Thrombocytosis was observed in patients with chronic ITP after SARS‐CoV‐2 infection, frequently needing treatment adjustment or even discontinuation of therapy. Relapses and newly diagnosed cases showed a fast response after initial treatment compared to ITP. Reduced immune activity due to lymphopenia during COVID‐19 could explain this paradoxical effect, although further studies are needed.
ISSN:	0007-1048 1365-2141
DOI:	10.1111/bjh.17077