Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study
Objective To evaluate trappin‐2 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB. Methods Trappin‐2 levels assessed in cervicovaginal secretions collected from...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2021-07, Vol.154 (1), p.56-61 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Negi, Deepika Guleria, Kiran Tyagi, Vipin Dev Banerjee, Basu Suneja, Amita |
| description | Objective
To evaluate trappin‐2 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB.
Methods
Trappin‐2 levels assessed in cervicovaginal secretions collected from 80 asymptomatic pregnant women at high risk for preterm delivery and cervical length measured by TVS, first at 14–20 weeks of pregnancy and repeated 8 weeks later. On the basis of delivery outcomes, participants were divided into cases (delivery |
| doi_str_mv | 10.1002/ijgo.13512 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2467618902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2467618902</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3292-1628d11fb5777201f4cc8dc07c0d4ee6e5484e16baf4807865ce9c1718f610dd3</originalsourceid><addsrcrecordid>eNp9kc1O3DAURq0KBFPKpg-AvERIAV8nEyfsKsSvEGzoOvLYNzOGJA62M2h2PAJv0Hfrk9Qh0CUrL77jc339EfIT2DEwxk_M49IeQzoH_o3MoBBlkmai3CKzGLJE8JLvku_ePzLGQADskN005WIuBJ-RP-dr2QwyGNtRW9PgZN-b7u_rG6emowrd2ii7lkvTyYZ6VA5H1FPpae9QGxWsGy_63nZBdmiH9yCga-nCuLAaNdJv2j7YNo5RdGWWq-h3xj_RF9tid0rv0AfUVEmPMVHR5GycFga9-UG2a9l43P8498jvi_OHs6vk9v7y-uzXbaLSuF8COS80QL2IWwnOoM6UKrRiQjGdIeY4z4oMIV_IOiuYKPK5wlLF3yjqHJjW6R45nLy9s89DfE_VGq-waaadKp7lIoeiZDyiRxOqnPXeYV31zrTSbSpg1VhINRZSvRcS4YMP77BoUf9HPxuIAEzAi2lw84Wqur65vJ-k_wC0pZzC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2467618902</pqid></control><display><type>article</type><title>Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study</title><source>Wiley Journals</source><creator>Negi, Deepika ; Guleria, Kiran ; Tyagi, Vipin ; Dev Banerjee, Basu ; Suneja, Amita</creator><creatorcontrib>Negi, Deepika ; Guleria, Kiran ; Tyagi, Vipin ; Dev Banerjee, Basu ; Suneja, Amita</creatorcontrib><description>Objective
To evaluate trappin‐2 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB.
Methods
Trappin‐2 levels assessed in cervicovaginal secretions collected from 80 asymptomatic pregnant women at high risk for preterm delivery and cervical length measured by TVS, first at 14–20 weeks of pregnancy and repeated 8 weeks later. On the basis of delivery outcomes, participants were divided into cases (delivery <37 weeks) and controls (delivery at 37–41 weeks).
Results
The mean value of cervicovaginal trappin‐2 was significantly higher in women who delivered preterm (n = 40), compared with the term group (n = 40: P < 0.001) both at 14–20 weeks and at 22–28 weeks. The critical cut‐off value for cervicovaginal trappin‐2 at 14–20 weeks was 4620 pg/mL, above which participants delivered prematurely with sensitivity, specificity, and positive and negative predictive values of 82.5%, 71.0%, 78.5%, and 81.5% respectively, whereas TVS cervical length in this window period was not significantly associated with preterm birth. At 22–28 weeks a trappin‐2 value of 6900 pg/mL had similar predictive accuracy.
Conclusion
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of PTB as early as 14–20 weeks (earlier than TVS) in asymptomatic high‐risk women.
Synopsis
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of preterm birth as early as 14–20 weeks of pregnancy in asymptomatic high‐risk women.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.13512</identifier><identifier>PMID: 33275772</identifier><language>eng</language><publisher>United States</publisher><subject>cervical length ; cervicovaginal secretions ; Indian study ; inflammation ; predictor ; preterm birth ; transvaginal ultrasonography ; trappin‐2</subject><ispartof>International journal of gynecology and obstetrics, 2021-07, Vol.154 (1), p.56-61</ispartof><rights>2020 International Federation of Gynecology and Obstetrics</rights><rights>2020 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3292-1628d11fb5777201f4cc8dc07c0d4ee6e5484e16baf4807865ce9c1718f610dd3</citedby><cites>FETCH-LOGICAL-c3292-1628d11fb5777201f4cc8dc07c0d4ee6e5484e16baf4807865ce9c1718f610dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.13512$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.13512$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33275772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Negi, Deepika</creatorcontrib><creatorcontrib>Guleria, Kiran</creatorcontrib><creatorcontrib>Tyagi, Vipin</creatorcontrib><creatorcontrib>Dev Banerjee, Basu</creatorcontrib><creatorcontrib>Suneja, Amita</creatorcontrib><title>Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To evaluate trappin‐2 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB.
Methods
Trappin‐2 levels assessed in cervicovaginal secretions collected from 80 asymptomatic pregnant women at high risk for preterm delivery and cervical length measured by TVS, first at 14–20 weeks of pregnancy and repeated 8 weeks later. On the basis of delivery outcomes, participants were divided into cases (delivery <37 weeks) and controls (delivery at 37–41 weeks).
Results
The mean value of cervicovaginal trappin‐2 was significantly higher in women who delivered preterm (n = 40), compared with the term group (n = 40: P < 0.001) both at 14–20 weeks and at 22–28 weeks. The critical cut‐off value for cervicovaginal trappin‐2 at 14–20 weeks was 4620 pg/mL, above which participants delivered prematurely with sensitivity, specificity, and positive and negative predictive values of 82.5%, 71.0%, 78.5%, and 81.5% respectively, whereas TVS cervical length in this window period was not significantly associated with preterm birth. At 22–28 weeks a trappin‐2 value of 6900 pg/mL had similar predictive accuracy.
Conclusion
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of PTB as early as 14–20 weeks (earlier than TVS) in asymptomatic high‐risk women.
Synopsis
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of preterm birth as early as 14–20 weeks of pregnancy in asymptomatic high‐risk women.</description><subject>cervical length</subject><subject>cervicovaginal secretions</subject><subject>Indian study</subject><subject>inflammation</subject><subject>predictor</subject><subject>preterm birth</subject><subject>transvaginal ultrasonography</subject><subject>trappin‐2</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3DAURq0KBFPKpg-AvERIAV8nEyfsKsSvEGzoOvLYNzOGJA62M2h2PAJv0Hfrk9Qh0CUrL77jc339EfIT2DEwxk_M49IeQzoH_o3MoBBlkmai3CKzGLJE8JLvku_ePzLGQADskN005WIuBJ-RP-dr2QwyGNtRW9PgZN-b7u_rG6emowrd2ii7lkvTyYZ6VA5H1FPpae9QGxWsGy_63nZBdmiH9yCga-nCuLAaNdJv2j7YNo5RdGWWq-h3xj_RF9tid0rv0AfUVEmPMVHR5GycFga9-UG2a9l43P8498jvi_OHs6vk9v7y-uzXbaLSuF8COS80QL2IWwnOoM6UKrRiQjGdIeY4z4oMIV_IOiuYKPK5wlLF3yjqHJjW6R45nLy9s89DfE_VGq-waaadKp7lIoeiZDyiRxOqnPXeYV31zrTSbSpg1VhINRZSvRcS4YMP77BoUf9HPxuIAEzAi2lw84Wqur65vJ-k_wC0pZzC</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Negi, Deepika</creator><creator>Guleria, Kiran</creator><creator>Tyagi, Vipin</creator><creator>Dev Banerjee, Basu</creator><creator>Suneja, Amita</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202107</creationdate><title>Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study</title><author>Negi, Deepika ; Guleria, Kiran ; Tyagi, Vipin ; Dev Banerjee, Basu ; Suneja, Amita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3292-1628d11fb5777201f4cc8dc07c0d4ee6e5484e16baf4807865ce9c1718f610dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cervical length</topic><topic>cervicovaginal secretions</topic><topic>Indian study</topic><topic>inflammation</topic><topic>predictor</topic><topic>preterm birth</topic><topic>transvaginal ultrasonography</topic><topic>trappin‐2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Negi, Deepika</creatorcontrib><creatorcontrib>Guleria, Kiran</creatorcontrib><creatorcontrib>Tyagi, Vipin</creatorcontrib><creatorcontrib>Dev Banerjee, Basu</creatorcontrib><creatorcontrib>Suneja, Amita</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Negi, Deepika</au><au>Guleria, Kiran</au><au>Tyagi, Vipin</au><au>Dev Banerjee, Basu</au><au>Suneja, Amita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2021-07</date><risdate>2021</risdate><volume>154</volume><issue>1</issue><spage>56</spage><epage>61</epage><pages>56-61</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective
To evaluate trappin‐2 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB.
Methods
Trappin‐2 levels assessed in cervicovaginal secretions collected from 80 asymptomatic pregnant women at high risk for preterm delivery and cervical length measured by TVS, first at 14–20 weeks of pregnancy and repeated 8 weeks later. On the basis of delivery outcomes, participants were divided into cases (delivery <37 weeks) and controls (delivery at 37–41 weeks).
Results
The mean value of cervicovaginal trappin‐2 was significantly higher in women who delivered preterm (n = 40), compared with the term group (n = 40: P < 0.001) both at 14–20 weeks and at 22–28 weeks. The critical cut‐off value for cervicovaginal trappin‐2 at 14–20 weeks was 4620 pg/mL, above which participants delivered prematurely with sensitivity, specificity, and positive and negative predictive values of 82.5%, 71.0%, 78.5%, and 81.5% respectively, whereas TVS cervical length in this window period was not significantly associated with preterm birth. At 22–28 weeks a trappin‐2 value of 6900 pg/mL had similar predictive accuracy.
Conclusion
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of PTB as early as 14–20 weeks (earlier than TVS) in asymptomatic high‐risk women.
Synopsis
Raised cervicovaginal trappin‐2 levels can be used as an early tool for prediction of preterm birth as early as 14–20 weeks of pregnancy in asymptomatic high‐risk women.</abstract><cop>United States</cop><pmid>33275772</pmid><doi>10.1002/ijgo.13512</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Journals |
| subjects | cervical length cervicovaginal secretions Indian study inflammation predictor preterm birth transvaginal ultrasonography trappin‐2 |
| title | Evaluation of trappin‐2 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high‐risk women: Nested case‐control study |
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