Gut mycobiome: A promising target for colorectal cancer

The human gut is mainly habited by a staggering amount and abundance of bacteria as well as fungi. Gut dysbiosis is believed as a pivotal factor in colorectal cancer (CRC) development. Lately increasing evidence from animal or clinical studies suggested that fungal disturbance also contributed to CR...

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Veröffentlicht in:	Biochimica et biophysica acta. Reviews on cancer 2021-01, Vol.1875 (1), p.188489-188489, Article 188489
Hauptverfasser:	Qin, Xiali, Gu, Yu, Liu, Tianyu, Wang, Chen, Zhong, Weilong, Wang, Bangmao, Cao, Hailong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - genetics Bacteria - pathogenicity Caspase recruitment domain-containing protein 9 Colorectal cancer Colorectal Neoplasms - etiology Colorectal Neoplasms - genetics Colorectal Neoplasms - microbiology Colorectal Neoplasms - pathology Dysbiosis Dysbiosis - complications Dysbiosis - genetics Dysbiosis - microbiology Dysbiosis - pathology Fungi - genetics Fungi - pathogenicity Gastrointestinal Microbiome - genetics Gut mycobiome Humans Mycobiome - genetics Therapy
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Zusammenfassung:	The human gut is mainly habited by a staggering amount and abundance of bacteria as well as fungi. Gut dysbiosis is believed as a pivotal factor in colorectal cancer (CRC) development. Lately increasing evidence from animal or clinical studies suggested that fungal disturbance also contributed to CRC development. This review summarized the current status of fungal dysbiosis in CRC and highlighted the potential tumorigenic mechanisms of fungi. Then the fungal markers and some therapeutic strategies for CRC were discussed. It would provide a better understanding of the correlation of mycobiota and CRC, and modulating fungal community would be a promising target against CRC.
ISSN:	0304-419X 1879-2561
DOI:	10.1016/j.bbcan.2020.188489