A Kinetic Model for Spray-Freezing of Pharmaceuticals

A Kinetic Model for Spray-Freezing of Pharmaceuticals

Spray freeze-drying (SFD), which includes spray-freezing into droplets and dynamic vacuum drying, presents a promising alternative approach to manufacture dried pharmaceuticals more efficiently than conventional vial freeze-drying. Without reliable predictive models for the SFD conditions of interes...

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Veröffentlicht in:Journal of pharmaceutical sciences 2021-05, Vol.110 (5), p.2047-2062
Hauptverfasser: Borges Sebastião, Israel, Bhatnagar, Bakul, Tchessalov, Serguei
Format: Artikel
Sprache:eng
Schlagworte:
Crystallization
Freeze-drying
In silico modeling
Lyophilization
Mechanistic modeling
Microsphere(s)
Powder technology(s)
Spray freeze-drying
Sucrose
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Beschreibung
Zusammenfassung:Spray freeze-drying (SFD), which includes spray-freezing into droplets and dynamic vacuum drying, presents a promising alternative approach to manufacture dried pharmaceuticals more efficiently than conventional vial freeze-drying. Without reliable predictive models for the SFD conditions of interest, any respective process development still relies on empirical approaches. In this work, we propose an improved modeling framework to describe the fast freezing (
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2020.11.032