Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)
We analyzed association of rs4680 polymorphism of catechol-O-methyltransferase ( COMT ) gene with clinical parameters of the tumor in patients with colorectal cancer ( n =100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and s...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-12, Vol.170 (2), p.254-257 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 170 |
| creator | Ivanova, T. I. Potapov, A. L. Zemskova, D. V. Khorokhorina, V. A. Shegai, P. V. Ivanov, S. A. Kaprin, A. D. |
| description | We analyzed association of
rs4680
polymorphism of catechol-O-methyltransferase (
COMT
) gene with clinical parameters of the tumor in patients with colorectal cancer (
n
=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2
vs
Т3+Т4) and the presence of regional (N0
vs
N1) and distant metastases (M0
vs
M1). An association of the
AA
genotype with an almost 7-fold increased capacity for invasive tumor growth was found (
p |
| doi_str_mv | 10.1007/s10517-020-05046-7 |
| format | Article |
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rs4680
polymorphism of catechol-O-methyltransferase (
COMT
) gene with clinical parameters of the tumor in patients with colorectal cancer (
n
=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2
vs
Т3+Т4) and the presence of regional (N0
vs
N1) and distant metastases (M0
vs
M1). An association of the
AA
genotype with an almost 7-fold increased capacity for invasive tumor growth was found (
p
<0.05; according to recessive (
AA vs GG
+
GA
) and codominant (
AA vs GG
) inheritance models). A positive relationship of minor allele
A
with increased malignancy of tumor cells was revealed at the trend level. No significant associations with either regional or distant metastasis were found.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-020-05046-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer ; Catechol ; Catechol O-methyltransferase ; Cell Biology ; Colorectal cancer ; Colorectal carcinoma ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Heredity ; Internal Medicine ; Invasiveness ; Laboratory Medicine ; Malignancy ; Metastases ; Methyltransferase ; Oncology, Experimental ; Pathology ; Polymorphism ; Tumor cells ; Tumors</subject><ispartof>Bulletin of experimental biology and medicine, 2020-12, Vol.170 (2), p.254-257</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c401t-e68e6b04ea5c00d32a97b4c4a4012c0ae17207f0ea586b522f0f353c3dc9f9c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-020-05046-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-020-05046-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Ivanova, T. I.</creatorcontrib><creatorcontrib>Potapov, A. L.</creatorcontrib><creatorcontrib>Zemskova, D. V.</creatorcontrib><creatorcontrib>Khorokhorina, V. A.</creatorcontrib><creatorcontrib>Shegai, P. V.</creatorcontrib><creatorcontrib>Ivanov, S. A.</creatorcontrib><creatorcontrib>Kaprin, A. D.</creatorcontrib><title>Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>We analyzed association of
rs4680
polymorphism of catechol-O-methyltransferase (
COMT
) gene with clinical parameters of the tumor in patients with colorectal cancer (
n
=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2
vs
Т3+Т4) and the presence of regional (N0
vs
N1) and distant metastases (M0
vs
M1). An association of the
AA
genotype with an almost 7-fold increased capacity for invasive tumor growth was found (
p
<0.05; according to recessive (
AA vs GG
+
GA
) and codominant (
AA vs GG
) inheritance models). A positive relationship of minor allele
A
with increased malignancy of tumor cells was revealed at the trend level. No significant associations with either regional or distant metastasis were found.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Catechol</subject><subject>Catechol O-methyltransferase</subject><subject>Cell Biology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Heredity</subject><subject>Internal Medicine</subject><subject>Invasiveness</subject><subject>Laboratory Medicine</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Methyltransferase</subject><subject>Oncology, Experimental</subject><subject>Pathology</subject><subject>Polymorphism</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kkuLFDEUhQtRsB39A64CgoyLGm9elfSyKcYHjEyD7TqkU6npDKmkTVIDvfaPm7bVcUQki5B7v3O4l5ymeYnhAgOItxkDx6IFAi1wYF0rHjULzAVtJSH4cbOASrVMSvm0eZbz7fEJHV403y7vtJ91cTGgOKKys2iVczTudyll1klA_fWnDVpHf5hi2u9cnpAOA-q9C85oj9Y66ckWm_Ivm81cSeQC6qOPyZpSqV4HYxM612jtfCzoc5mHw5vnzZNR-2xf_LzPmi_vLjf9h_bq-v3HfnXVGga4tLaTttsCs5obgIESvRRbZpiuXWJAWywIiBFqX3ZbTsgII-XU0MEsx6Xh9Kw5P_nuU_w621zU5LKx3utg45wVYV1HpGCcVfTVX-htnFOo01VKUNoxIfk9daO9VS6MsSRtjqZq1XHMMcGSVuriH1Q9g52cicGOrtYfCF7_IdhZ7csuRz8ffyQ_BMkJNCnmnOyo9slNOh0UBnXMhTrlQtVcqB-5UKKK6EmUKxxubLpf7T-q71Cft0E</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Ivanova, T. I.</creator><creator>Potapov, A. L.</creator><creator>Zemskova, D. V.</creator><creator>Khorokhorina, V. A.</creator><creator>Shegai, P. V.</creator><creator>Ivanov, S. A.</creator><creator>Kaprin, A. D.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)</title><author>Ivanova, T. I. ; Potapov, A. L. ; Zemskova, D. V. ; Khorokhorina, V. A. ; Shegai, P. V. ; Ivanov, S. A. ; Kaprin, A. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e68e6b04ea5c00d32a97b4c4a4012c0ae17207f0ea586b522f0f353c3dc9f9c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Catechol</topic><topic>Catechol O-methyltransferase</topic><topic>Cell Biology</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Gene polymorphism</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Heredity</topic><topic>Internal Medicine</topic><topic>Invasiveness</topic><topic>Laboratory Medicine</topic><topic>Malignancy</topic><topic>Metastases</topic><topic>Methyltransferase</topic><topic>Oncology, Experimental</topic><topic>Pathology</topic><topic>Polymorphism</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivanova, T. I.</creatorcontrib><creatorcontrib>Potapov, A. L.</creatorcontrib><creatorcontrib>Zemskova, D. V.</creatorcontrib><creatorcontrib>Khorokhorina, V. A.</creatorcontrib><creatorcontrib>Shegai, P. V.</creatorcontrib><creatorcontrib>Ivanov, S. A.</creatorcontrib><creatorcontrib>Kaprin, A. D.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivanova, T. I.</au><au>Potapov, A. L.</au><au>Zemskova, D. V.</au><au>Khorokhorina, V. A.</au><au>Shegai, P. V.</au><au>Ivanov, S. A.</au><au>Kaprin, A. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>170</volume><issue>2</issue><spage>254</spage><epage>257</epage><pages>254-257</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We analyzed association of
rs4680
polymorphism of catechol-O-methyltransferase (
COMT
) gene with clinical parameters of the tumor in patients with colorectal cancer (
n
=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2
vs
Т3+Т4) and the presence of regional (N0
vs
N1) and distant metastases (M0
vs
M1). An association of the
AA
genotype with an almost 7-fold increased capacity for invasive tumor growth was found (
p
<0.05; according to recessive (
AA vs GG
+
GA
) and codominant (
AA vs GG
) inheritance models). A positive relationship of minor allele
A
with increased malignancy of tumor cells was revealed at the trend level. No significant associations with either regional or distant metastasis were found.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10517-020-05046-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2020-12, Vol.170 (2), p.254-257 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2466287454 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Catechol Catechol O-methyltransferase Cell Biology Colorectal cancer Colorectal carcinoma Gene polymorphism Genetic aspects Genetic polymorphisms Heredity Internal Medicine Invasiveness Laboratory Medicine Malignancy Metastases Methyltransferase Oncology, Experimental Pathology Polymorphism Tumor cells Tumors |
| title | Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study) |
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