Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)

Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)

We analyzed association of rs4680 polymorphism of catechol-O-methyltransferase ( COMT ) gene with clinical parameters of the tumor in patients with colorectal cancer ( n =100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and s...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2020-12, Vol.170 (2), p.254-257
Hauptverfasser: Ivanova, T. I., Potapov, A. L., Zemskova, D. V., Khorokhorina, V. A., Shegai, P. V., Ivanov, S. A., Kaprin, A. D.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cancer
Catechol
Catechol O-methyltransferase
Cell Biology
Colorectal cancer
Colorectal carcinoma
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Heredity
Internal Medicine
Invasiveness
Laboratory Medicine
Malignancy
Metastases
Methyltransferase
Oncology, Experimental
Pathology
Polymorphism
Tumor cells
Tumors
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Zusammenfassung:We analyzed association of rs4680 polymorphism of catechol-O-methyltransferase ( COMT ) gene with clinical parameters of the tumor in patients with colorectal cancer ( n =100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2 vs Т3+Т4) and the presence of regional (N0 vs N1) and distant metastases (M0 vs M1). An association of the AA genotype with an almost 7-fold increased capacity for invasive tumor growth was found ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-05046-7