Tumor Burden Dictates Prognosis Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma: A Tool to Guide Post-Resection Adjuvant Chemotherapy?

Tumor Burden Dictates Prognosis Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma: A Tool to Guide Post-Resection Adjuvant Chemotherapy?

Introduction While tumor burden (TB) has been associated with outcomes among patients with hepatocellular carcinoma, the role of overall TB in intrahepatic cholangiocarcinoma (ICC) remains poorly defined. Methods Patients undergoing curative-intent resection of ICC between 2000 and 2017 were identif...

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Veröffentlicht in:Annals of surgical oncology 2021-04, Vol.28 (4), p.1970-1978
Hauptverfasser: Tsilimigras, Diamantis I., Hyer, J. Madison, Paredes, Anghela Z., Moris, Dimitrios, Sahara, Kota, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, Sasaki, Kazunari, Aucejo, Federico, Zhang, Xu-Feng, Pawlik, Timothy M.
Format: Artikel
Sprache:eng
Schlagworte:
Bile Duct Neoplasms - drug therapy
Bile Duct Neoplasms - surgery
Chemotherapy
Chemotherapy, Adjuvant
Cholangiocarcinoma
Cholangiocarcinoma - drug therapy
Cholangiocarcinoma - surgery
Hepatectomy
Hepatobiliary Tumors
Hepatocellular carcinoma
Humans
Liver cancer
Medical prognosis
Medicine
Medicine & Public Health
Oncology
Prognosis
Surgery
Surgical Oncology
Survival
Survival analysis
Tumor Burden
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Zusammenfassung:Introduction While tumor burden (TB) has been associated with outcomes among patients with hepatocellular carcinoma, the role of overall TB in intrahepatic cholangiocarcinoma (ICC) remains poorly defined. Methods Patients undergoing curative-intent resection of ICC between 2000 and 2017 were identified from a multi-institutional database. The impact of TB on overall (OS) and disease-free survival (DFS) was evaluated in the multi-institutional database and validated externally. Results Among 1101 patients who underwent curative-intent resection of ICC, 624 (56.7%) had low TB, 346 (31.4%) medium TB, and 131 (11.9%) high TB. OS incrementally worsened with higher TB (5-year OS; low TB: 48.3% vs medium TB: 29.8% vs high TB: 17.3%, p 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09393-7