Noncoding RNA, Intragenomic Conflict, and Rodent SRY Evolution

Noncoding RNA, Intragenomic Conflict, and Rodent SRY Evolution

The sex-determining gene SRY has undergone rapid evolution in rodents. Curiously, a new study by Miyawaki et al. reveals that a recently evolved SRY gene sequence antagonizes SRY protein stability, necessitating splicing of a novel intron. Other data suggest that this troublesome gene region has non...

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Veröffentlicht in:Trends in genetics 2021-02, Vol.37 (2), p.102-104
1. Verfasser: Roy, Scott William
Format: Artikel
Sprache:eng
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Zusammenfassung:The sex-determining gene SRY has undergone rapid evolution in rodents. Curiously, a new study by Miyawaki et al. reveals that a recently evolved SRY gene sequence antagonizes SRY protein stability, necessitating splicing of a novel intron. Other data suggest that this troublesome gene region has noncoding RNA functions, possibly related to conflict between sex chromosomes.
ISSN:0168-9525
DOI:10.1016/j.tig.2020.11.004