Relation between HLA-DP/DQ Polymorphisms, Serum IP-10 and Response to Direct Acting Antiviral Therapy among HCV Infected Patients

Relation between HLA-DP/DQ Polymorphisms, Serum IP-10 and Response to Direct Acting Antiviral Therapy among HCV Infected Patients

HCV infection represents a worldwide health problem with many attempts to control. This study aimed to assess the relation between HLA-DQ-rs3920 SNP, HLA-DP-rs3077 SNP, serum IP-10 levels and response to direct acting antiviral (DAA) drugs among HCV infected Egyptian patients. The study included 100...

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Veröffentlicht in:The Egyptian journal of immunology 2020-01, Vol.27 (1), p.177-185
Hauptverfasser: Ghazy, Amany A, Haydara, Tamer, Farooq, Umar D, Nadwa, Eman H, Ghazy, Haneen A, Amer, Ibrahim
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral Agents - therapeutic use
Chemokine CXCL10 - blood
Egypt
Genotype
Hepatitis C - drug therapy
Hepatitis C - genetics
HLA-DP Antigens - genetics
HLA-DQ Antigens - genetics
Humans
Polymorphism, Single Nucleotide
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Zusammenfassung:HCV infection represents a worldwide health problem with many attempts to control. This study aimed to assess the relation between HLA-DQ-rs3920 SNP, HLA-DP-rs3077 SNP, serum IP-10 levels and response to direct acting antiviral (DAA) drugs among HCV infected Egyptian patients. The study included 100 HCV infected patients (received sofosbuvir, Daclatsvir and Ribavirin) and 50 apparently healthy volunteers as controls. Serological, hematological and viral investigations were done to all participants. Whole DNA was extracted, HLA-DQ-rs3920 SNP and HLA-DP-rs3077 SNP were evaluated using RT-PCR and serum IP-10 levels were determined. Higher frequencies of HLA-DQ rs3920 AG and HLA-DP rs3077 AA variants was observed among HCV infected patients (P
ISSN:1110-4902