Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide

Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide

Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfa...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2020-11, Vol.170 (1), p.171-174
Hauptverfasser: Safonova, E. A., Lopatina, K. A., Dyagel, A. R., Razina, T. G., Krylova, S. G., Gur’ev, A. M., Belousov, M. V., Zueva, E. P.
Format: Artikel
Sprache:eng
Schlagworte:
Antimitotic agents
Antineoplastic agents
Antineoplastic drugs
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell Biology
Chemotherapy
Cyclophosphamide
Hematopoietic stem cells
Internal Medicine
Laboratory Medicine
Myelosuppression
Pathology
Polysaccharides
Stem cell transplantation
Stem cells
Tussilago farfara
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Zusammenfassung:Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117 + 34 + ) in the bone marrow.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-05025-y