Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation
Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing...
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| Veröffentlicht in: | Journal of neuroimmunology 2021-01, Vol.350, p.577446-577446, Article 577446 |
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| container_title | Journal of neuroimmunology |
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| creator | Drummond, Juliana B. Soares, Beatriz S. Vieira, Erica L.M. Pedrosa, William Teixeira, Antonio L. Ribeiro-Oliveira, Antônio |
| description | Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance test. Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P |
| doi_str_mv | 10.1016/j.jneuroim.2020.577446 |
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•IL-6 plasma levels significantly increase following symptomatic acute hypoglycemia.•IL-6 response is associated with the co-activation of the HPA axis.•IL-6 increase is reduced in patients with impaired HPA axis response.•IL-6 increase correlates with patient discomfort during insulin hypoglycemic stress.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2020.577446</identifier><identifier>PMID: 33227660</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Counter-regulatory response ; Hypoglycemia ; Hypothalamic-pituitary-adrenal axis ; Insulin-tolerance-test ; Interleukin-6 ; Stress</subject><ispartof>Journal of neuroimmunology, 2021-01, Vol.350, p.577446-577446, Article 577446</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-aead03a52309599af13d3bc7e91e75af417b22ca0400f5f79fe4f870b011e9533</citedby><cites>FETCH-LOGICAL-c368t-aead03a52309599af13d3bc7e91e75af417b22ca0400f5f79fe4f870b011e9533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2020.577446$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33227660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drummond, Juliana B.</creatorcontrib><creatorcontrib>Soares, Beatriz S.</creatorcontrib><creatorcontrib>Vieira, Erica L.M.</creatorcontrib><creatorcontrib>Pedrosa, William</creatorcontrib><creatorcontrib>Teixeira, Antonio L.</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, Antônio</creatorcontrib><title>Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance test. Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P < 0.001 for all variables). Patients with insufficient HPA axis response had lower hypoglycemia-induced IL-6 increase (median: 0.88 pg/mL) compared with individuals with intact HPA axis response (2.03 pg/mL, P = 0.007). IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). In conclusion, hypoglycemic stress-induced IL-6 increase is associated with activation of the HPA axis, suggesting that IL-6 response to hypoglycemic stress may be regarded as part of the counter-regulatory response, possibly contributing to the maintenance of glucose homeostasis.
[Display omitted]
•IL-6 plasma levels significantly increase following symptomatic acute hypoglycemia.•IL-6 response is associated with the co-activation of the HPA axis.•IL-6 increase is reduced in patients with impaired HPA axis response.•IL-6 increase correlates with patient discomfort during insulin hypoglycemic stress.</description><subject>Counter-regulatory response</subject><subject>Hypoglycemia</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Insulin-tolerance-test</subject><subject>Interleukin-6</subject><subject>Stress</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EotvCX6hy5JKtv53cQBUflSpxgbPldSbsLIkdbKd0_z1etuXKaaSZ553RPIRcM7pllOmbw_YQYE0R5y2nnG6VMVLqF2TDOsPbTnL2kmwqqFpleHdBLnM-UMqUkP1rciEE50ZruiGPd6FAmmD9iaHVTYK8xJChKbHBkNepdjEMq4eh2R-X-GM6epjRNZgbl3P06Eod_cay_zsveze5GX27YFmxuHRs3ZAguKlxj6eML_jgCsbwhrwa3ZTh7VO9It8_ffx2-6W9__r57vbDfeuF7krrwA1UOMUF7VXfu5GJQey8gZ6BUW6UzOw4945KSkc1mn4EOXaG7ihj0Cshrsi7894lxV8r5GJnzB6myQWIa7ZcasmkVr2sqD6jPsWcE4x2STjXHyyj9mTdHuyzdXuybs_Wa_D66ca6m2H4F3vWXIH3ZwDqpw8IyWaPEKpVTOCLHSL-78YfrJqaRw</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Drummond, Juliana B.</creator><creator>Soares, Beatriz S.</creator><creator>Vieira, Erica L.M.</creator><creator>Pedrosa, William</creator><creator>Teixeira, Antonio L.</creator><creator>Ribeiro-Oliveira, Antônio</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210115</creationdate><title>Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation</title><author>Drummond, Juliana B. ; Soares, Beatriz S. ; Vieira, Erica L.M. ; Pedrosa, William ; Teixeira, Antonio L. ; Ribeiro-Oliveira, Antônio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-aead03a52309599af13d3bc7e91e75af417b22ca0400f5f79fe4f870b011e9533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Counter-regulatory response</topic><topic>Hypoglycemia</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Insulin-tolerance-test</topic><topic>Interleukin-6</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drummond, Juliana B.</creatorcontrib><creatorcontrib>Soares, Beatriz S.</creatorcontrib><creatorcontrib>Vieira, Erica L.M.</creatorcontrib><creatorcontrib>Pedrosa, William</creatorcontrib><creatorcontrib>Teixeira, Antonio L.</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, Antônio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drummond, Juliana B.</au><au>Soares, Beatriz S.</au><au>Vieira, Erica L.M.</au><au>Pedrosa, William</au><au>Teixeira, Antonio L.</au><au>Ribeiro-Oliveira, Antônio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>350</volume><spage>577446</spage><epage>577446</epage><pages>577446-577446</pages><artnum>577446</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance test. Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P < 0.001 for all variables). Patients with insufficient HPA axis response had lower hypoglycemia-induced IL-6 increase (median: 0.88 pg/mL) compared with individuals with intact HPA axis response (2.03 pg/mL, P = 0.007). IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). In conclusion, hypoglycemic stress-induced IL-6 increase is associated with activation of the HPA axis, suggesting that IL-6 response to hypoglycemic stress may be regarded as part of the counter-regulatory response, possibly contributing to the maintenance of glucose homeostasis.
[Display omitted]
•IL-6 plasma levels significantly increase following symptomatic acute hypoglycemia.•IL-6 response is associated with the co-activation of the HPA axis.•IL-6 increase is reduced in patients with impaired HPA axis response.•IL-6 increase correlates with patient discomfort during insulin hypoglycemic stress.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33227660</pmid><doi>10.1016/j.jneuroim.2020.577446</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Counter-regulatory response Hypoglycemia Hypothalamic-pituitary-adrenal axis Insulin-tolerance-test Interleukin-6 Stress |
| title | Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation |
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