Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation

Interleukin-6 response to insulin-induced hypoglycemia is associated with hypothalamic-pituitary-adrenal axis activation

Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing...

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Veröffentlicht in:Journal of neuroimmunology 2021-01, Vol.350, p.577446-577446, Article 577446
Hauptverfasser: Drummond, Juliana B., Soares, Beatriz S., Vieira, Erica L.M., Pedrosa, William, Teixeira, Antonio L., Ribeiro-Oliveira, Antônio
Format: Artikel
Sprache:eng
Schlagworte:
Counter-regulatory response
Hypoglycemia
Hypothalamic-pituitary-adrenal axis
Insulin-tolerance-test
Interleukin-6
Stress
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Zusammenfassung:Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance test. Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2020.577446