STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review
Thymic mucinous adenocarcinoma is an extremely rare and aggressive subtype of thymic carcinoma, and there is no effective treatment for this disease except complete resection. Moreover, it is necessary to determine the efficacy and safety of multimodal treatments, including molecular targeted drugs...
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| Veröffentlicht in: | Clinical lung cancer 2021-09, Vol.22 (5), p.e659-e664 |
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| container_issue | 5 |
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| container_title | Clinical lung cancer |
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| creator | Himuro, Naoya Kitami, Akihiko Tanaka, Yoko Ohashi, Shinichi Suzuki, Kosuke Ohara, Jun Honma, Mayumi Nemoto, Tetsuo Takei, Hidefumi Kadokura, Mitsutaka |
| description | Thymic mucinous adenocarcinoma is an extremely rare and aggressive subtype of thymic carcinoma, and there is no effective treatment for this disease except complete resection. Moreover, it is necessary to determine the efficacy and safety of multimodal treatments, including molecular targeted drugs and immunotherapy.
Although a case of a thymic mucinous adenocarcinoma with KRAS gene mutation has been reported, there are no reports describing any other gene mutations in thymic mucinous adenocarcinomas. We herein present the first case of STK11/LKB1 mutationpositive primary thymic mucinous adenocarcinoma.
The findings of the current clinical case are expected to further the evaluations of gene mutations and aid in the development of therapeutic methods for primary thymic mucinous adenocarcinomas. (C) 2020 Elsevier Inc. All rights reserved. |
| doi_str_mv | 10.1016/j.cllc.2020.10.010 |
| format | Article |
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Although a case of a thymic mucinous adenocarcinoma with KRAS gene mutation has been reported, there are no reports describing any other gene mutations in thymic mucinous adenocarcinomas. We herein present the first case of STK11/LKB1 mutationpositive primary thymic mucinous adenocarcinoma.
The findings of the current clinical case are expected to further the evaluations of gene mutations and aid in the development of therapeutic methods for primary thymic mucinous adenocarcinomas. (C) 2020 Elsevier Inc. All rights reserved.</description><identifier>ISSN: 1525-7304</identifier><identifier>EISSN: 1938-0690</identifier><identifier>DOI: 10.1016/j.cllc.2020.10.010</identifier><identifier>PMID: 33221174</identifier><language>eng</language><publisher>DALLAS: Elsevier Inc</publisher><subject>Adenocarcinoma, Mucinous - genetics ; Adult ; AMP-Activated Protein Kinase Kinases - genetics ; FDG-PET ; Female ; Humans ; Life Sciences & Biomedicine ; Male ; Middle Aged ; mTOR inhibitors ; Mutation - genetics ; Oncology ; Radiotherapy ; Science & Technology ; Surgical resection ; Thymic cancer ; Thymus Neoplasms</subject><ispartof>Clinical lung cancer, 2021-09, Vol.22 (5), p.e659-e664</ispartof><rights>2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000729299500018</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c356t-267da7f5300d99ded66bac43866b4d9abd2920511f8160194cd08306ca23369e3</citedby><cites>FETCH-LOGICAL-c356t-267da7f5300d99ded66bac43866b4d9abd2920511f8160194cd08306ca23369e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cllc.2020.10.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33221174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Himuro, Naoya</creatorcontrib><creatorcontrib>Kitami, Akihiko</creatorcontrib><creatorcontrib>Tanaka, Yoko</creatorcontrib><creatorcontrib>Ohashi, Shinichi</creatorcontrib><creatorcontrib>Suzuki, Kosuke</creatorcontrib><creatorcontrib>Ohara, Jun</creatorcontrib><creatorcontrib>Honma, Mayumi</creatorcontrib><creatorcontrib>Nemoto, Tetsuo</creatorcontrib><creatorcontrib>Takei, Hidefumi</creatorcontrib><creatorcontrib>Kadokura, Mitsutaka</creatorcontrib><title>STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review</title><title>Clinical lung cancer</title><addtitle>CLIN LUNG CANCER</addtitle><addtitle>Clin Lung Cancer</addtitle><description>Thymic mucinous adenocarcinoma is an extremely rare and aggressive subtype of thymic carcinoma, and there is no effective treatment for this disease except complete resection. Moreover, it is necessary to determine the efficacy and safety of multimodal treatments, including molecular targeted drugs and immunotherapy.
Although a case of a thymic mucinous adenocarcinoma with KRAS gene mutation has been reported, there are no reports describing any other gene mutations in thymic mucinous adenocarcinomas. We herein present the first case of STK11/LKB1 mutationpositive primary thymic mucinous adenocarcinoma.
The findings of the current clinical case are expected to further the evaluations of gene mutations and aid in the development of therapeutic methods for primary thymic mucinous adenocarcinomas. (C) 2020 Elsevier Inc. All rights reserved.</description><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adult</subject><subject>AMP-Activated Protein Kinase Kinases - genetics</subject><subject>FDG-PET</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mTOR inhibitors</subject><subject>Mutation - genetics</subject><subject>Oncology</subject><subject>Radiotherapy</subject><subject>Science & Technology</subject><subject>Surgical resection</subject><subject>Thymic cancer</subject><subject>Thymus Neoplasms</subject><issn>1525-7304</issn><issn>1938-0690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkdGK1DAUhoso7rr6Al5ILgXp7EnSpq14MxZ3lZ1F0fG6pMkpZmibbpLuMg_hO5vScS9FCJzk8P2HnP9PktcUNhSouDxsVN-rDQO2NDZA4UlyTitepiAqeBrvOcvTgkN2lrzw_gDABKfseXLGOWOUFtl58vvH_obSy93NR0pu5yCDsWM6WW-CuUfyzZlBuiPZ_zoORkVAmdHOnmw1jlZJtzwHSbZK2WGSo0FN2iOp0WGLfS8ducUgfTzGvydbUkuP5DtO1gUiR012JqCTYXZL997gw8vkWSd7j69O9SL5efVpX39Od1-vv9TbXap4LkLKRKFl0eUcQFeVRi1EK1XGy1gzXclWs4pBTmlXUgG0ypSGkoNQknEuKuQXydt17uTs3Yw-NIPxavnyiHG_hmWCC4guioiyFVXOeu-wa6bVlIZCs8TQHJolhmaJYenFGKLozWn-3A6oHyV_fY_AuxV4wNZ2XhkcFT5iAFDEDaoqjzdaRrr8f7o2a4q1nccQpR9WKUY7o8WuOcm1cahCo6351yJ_AGZ0ub0</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Himuro, Naoya</creator><creator>Kitami, Akihiko</creator><creator>Tanaka, Yoko</creator><creator>Ohashi, Shinichi</creator><creator>Suzuki, Kosuke</creator><creator>Ohara, Jun</creator><creator>Honma, Mayumi</creator><creator>Nemoto, Tetsuo</creator><creator>Takei, Hidefumi</creator><creator>Kadokura, Mitsutaka</creator><general>Elsevier Inc</general><general>Cig Media Group, Lp</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review</title><author>Himuro, Naoya ; 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Moreover, it is necessary to determine the efficacy and safety of multimodal treatments, including molecular targeted drugs and immunotherapy.
Although a case of a thymic mucinous adenocarcinoma with KRAS gene mutation has been reported, there are no reports describing any other gene mutations in thymic mucinous adenocarcinomas. We herein present the first case of STK11/LKB1 mutationpositive primary thymic mucinous adenocarcinoma.
The findings of the current clinical case are expected to further the evaluations of gene mutations and aid in the development of therapeutic methods for primary thymic mucinous adenocarcinomas. (C) 2020 Elsevier Inc. All rights reserved.</abstract><cop>DALLAS</cop><pub>Elsevier Inc</pub><pmid>33221174</pmid><doi>10.1016/j.cllc.2020.10.010</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - genetics Adult AMP-Activated Protein Kinase Kinases - genetics FDG-PET Female Humans Life Sciences & Biomedicine Male Middle Aged mTOR inhibitors Mutation - genetics Oncology Radiotherapy Science & Technology Surgical resection Thymic cancer Thymus Neoplasms |
| title | STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review |
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