STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review

Thymic mucinous adenocarcinoma is an extremely rare and aggressive subtype of thymic carcinoma, and there is no effective treatment for this disease except complete resection. Moreover, it is necessary to determine the efficacy and safety of multimodal treatments, including molecular targeted drugs and immunotherapy. Although a case of a thymic mucinous adenocarcinoma with KRAS gene mutation has been reported, there are no reports describing any other gene mutations in thymic mucinous adenocarcinomas. We herein present the first case of STK11/LKB1 mutationpositive primary thymic mucinous adenocarcinoma. The findings of the current clinical case are expected to further the evaluations of gene mutations and aid in the development of therapeutic methods for primary thymic mucinous adenocarcinomas. (C) 2020 Elsevier Inc. All rights reserved.