Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures
Lung transplant recipients are at increased risk for infection in the early postoperative phase, thus perioperative antibiotics are employed. This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with...
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| Veröffentlicht in: | Transplant infectious disease 2021-06, Vol.23 (3), p.e13518-n/a |
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| container_title | Transplant infectious disease |
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| creator | Groff, Lindsey T. Reed, Erica E. Coe, Kelci E. El Boghdadly, Zeinab Keller, Brian C. Whitson, Bryan A. Burcham, Pamela K. |
| description | Lung transplant recipients are at increased risk for infection in the early postoperative phase, thus perioperative antibiotics are employed. This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with donor positive cultures between August 2013 and September 2019 were evaluated, excluding those with cystic fibrosis, death within 14 days and re‐transplants. The primary outcome was 30‐day freedom from donor‐derived respiratory infection. A total of 147 patients were included (57 short vs 90 long‐course). Median perioperative antibiotic duration was 6 days in the short‐course vs 14 days in the long‐course group (P |
| doi_str_mv | 10.1111/tid.13518 |
| format | Article |
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This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with donor positive cultures between August 2013 and September 2019 were evaluated, excluding those with cystic fibrosis, death within 14 days and re‐transplants. The primary outcome was 30‐day freedom from donor‐derived respiratory infection. A total of 147 patients were included (57 short vs 90 long‐course). Median perioperative antibiotic duration was 6 days in the short‐course vs 14 days in the long‐course group (P < .0001). Thirty‐day freedom from donor‐derived respiratory infection was present in 56 (98%) patients in the short‐course vs 85 (94%) patients in the long‐course group (P = .41). There was no difference in development of Clostridioides difficile infections (P = .41), while cumulative ventilator time and time to post‐op extubation were longer in the long‐course group (P = .001 and .004, respectively). Among lung transplant recipients with positive donor respiratory cultures, short‐course perioperative antibiotics were as effective as long‐course antibiotics in preventing donor‐derived bacterial respiratory infections.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.13518</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Antibiotics ; bacterial ; Cystic fibrosis ; donor‐derived ; Extubation ; Infections ; lung transplant ; Lung transplantation ; Lung transplants ; Lungs ; pneumonia ; Transplants</subject><ispartof>Transplant infectious disease, 2021-06, Vol.23 (3), p.e13518-n/a</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3658-4de781dc9565adfc948927832370eda31292cca2d14a37c6c5fd94b204eb24b33</citedby><cites>FETCH-LOGICAL-c3658-4de781dc9565adfc948927832370eda31292cca2d14a37c6c5fd94b204eb24b33</cites><orcidid>0000-0002-7073-3600 ; 0000-0003-3275-0597 ; 0000-0002-8536-350X ; 0000-0003-2997-6712 ; 0000-0003-0040-3638 ; 0000-0003-4382-7799</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftid.13518$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftid.13518$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Groff, Lindsey T.</creatorcontrib><creatorcontrib>Reed, Erica E.</creatorcontrib><creatorcontrib>Coe, Kelci E.</creatorcontrib><creatorcontrib>El Boghdadly, Zeinab</creatorcontrib><creatorcontrib>Keller, Brian C.</creatorcontrib><creatorcontrib>Whitson, Bryan A.</creatorcontrib><creatorcontrib>Burcham, Pamela K.</creatorcontrib><title>Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures</title><title>Transplant infectious disease</title><description>Lung transplant recipients are at increased risk for infection in the early postoperative phase, thus perioperative antibiotics are employed. This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with donor positive cultures between August 2013 and September 2019 were evaluated, excluding those with cystic fibrosis, death within 14 days and re‐transplants. The primary outcome was 30‐day freedom from donor‐derived respiratory infection. A total of 147 patients were included (57 short vs 90 long‐course). Median perioperative antibiotic duration was 6 days in the short‐course vs 14 days in the long‐course group (P < .0001). Thirty‐day freedom from donor‐derived respiratory infection was present in 56 (98%) patients in the short‐course vs 85 (94%) patients in the long‐course group (P = .41). There was no difference in development of Clostridioides difficile infections (P = .41), while cumulative ventilator time and time to post‐op extubation were longer in the long‐course group (P = .001 and .004, respectively). Among lung transplant recipients with positive donor respiratory cultures, short‐course perioperative antibiotics were as effective as long‐course antibiotics in preventing donor‐derived bacterial respiratory infections.</description><subject>Antibiotics</subject><subject>bacterial</subject><subject>Cystic fibrosis</subject><subject>donor‐derived</subject><subject>Extubation</subject><subject>Infections</subject><subject>lung transplant</subject><subject>Lung transplantation</subject><subject>Lung transplants</subject><subject>Lungs</subject><subject>pneumonia</subject><subject>Transplants</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kTtPxDAMxysEEs-BbxCJBYYezaOPjOg44KSTWGCOcqkLQSUpcQq6jZGRz8gnIdwxIeHBtuyfLcv_LDumxYQmO4-2nVBe0mYr26NcypwXFdte503OWM13s33Ep6KgtRRyL_uYdR2YaF_BASLxHcFHHyJ5RdJ79_D1_mn8GBDIAMH65PQPS7SLdml9tAaJdaQf3QOJQTsc-tQiAYwdLLiI5M3GR9J65wMZPNr1dAAcbNrkw4qYsY9jKhxmO53uEY5-40F2fzW7m97ki9vr-fRikRtelU0uWqgb2hpZVqVuOyNFI1ndcMbrAlrNKZPMGM1aKjSvTWXKrpViyQoBSyaWnB9kp5u9Q_AvI2BUzxYN9Olu8CMqJipOi6YpaUJP_qBP6RcuXadYKYTgTFCRqLMNZYJHDNCpIdhnHVaKFupHE5U0UWtNEnu-Yd9sD6v_QXU3v9xMfAOri5JM</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Groff, Lindsey T.</creator><creator>Reed, Erica E.</creator><creator>Coe, Kelci E.</creator><creator>El Boghdadly, Zeinab</creator><creator>Keller, Brian C.</creator><creator>Whitson, Bryan A.</creator><creator>Burcham, Pamela K.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7073-3600</orcidid><orcidid>https://orcid.org/0000-0003-3275-0597</orcidid><orcidid>https://orcid.org/0000-0002-8536-350X</orcidid><orcidid>https://orcid.org/0000-0003-2997-6712</orcidid><orcidid>https://orcid.org/0000-0003-0040-3638</orcidid><orcidid>https://orcid.org/0000-0003-4382-7799</orcidid></search><sort><creationdate>202106</creationdate><title>Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures</title><author>Groff, Lindsey T. ; Reed, Erica E. ; Coe, Kelci E. ; El Boghdadly, Zeinab ; Keller, Brian C. ; Whitson, Bryan A. ; Burcham, Pamela K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3658-4de781dc9565adfc948927832370eda31292cca2d14a37c6c5fd94b204eb24b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotics</topic><topic>bacterial</topic><topic>Cystic fibrosis</topic><topic>donor‐derived</topic><topic>Extubation</topic><topic>Infections</topic><topic>lung transplant</topic><topic>Lung transplantation</topic><topic>Lung transplants</topic><topic>Lungs</topic><topic>pneumonia</topic><topic>Transplants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Groff, Lindsey T.</creatorcontrib><creatorcontrib>Reed, Erica E.</creatorcontrib><creatorcontrib>Coe, Kelci E.</creatorcontrib><creatorcontrib>El Boghdadly, Zeinab</creatorcontrib><creatorcontrib>Keller, Brian C.</creatorcontrib><creatorcontrib>Whitson, Bryan A.</creatorcontrib><creatorcontrib>Burcham, Pamela K.</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Groff, Lindsey T.</au><au>Reed, Erica E.</au><au>Coe, Kelci E.</au><au>El Boghdadly, Zeinab</au><au>Keller, Brian C.</au><au>Whitson, Bryan A.</au><au>Burcham, Pamela K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures</atitle><jtitle>Transplant infectious disease</jtitle><date>2021-06</date><risdate>2021</risdate><volume>23</volume><issue>3</issue><spage>e13518</spage><epage>n/a</epage><pages>e13518-n/a</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>Lung transplant recipients are at increased risk for infection in the early postoperative phase, thus perioperative antibiotics are employed. This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with donor positive cultures between August 2013 and September 2019 were evaluated, excluding those with cystic fibrosis, death within 14 days and re‐transplants. The primary outcome was 30‐day freedom from donor‐derived respiratory infection. A total of 147 patients were included (57 short vs 90 long‐course). Median perioperative antibiotic duration was 6 days in the short‐course vs 14 days in the long‐course group (P < .0001). Thirty‐day freedom from donor‐derived respiratory infection was present in 56 (98%) patients in the short‐course vs 85 (94%) patients in the long‐course group (P = .41). There was no difference in development of Clostridioides difficile infections (P = .41), while cumulative ventilator time and time to post‐op extubation were longer in the long‐course group (P = .001 and .004, respectively). Among lung transplant recipients with positive donor respiratory cultures, short‐course perioperative antibiotics were as effective as long‐course antibiotics in preventing donor‐derived bacterial respiratory infections.</abstract><cop>Malden</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/tid.13518</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7073-3600</orcidid><orcidid>https://orcid.org/0000-0003-3275-0597</orcidid><orcidid>https://orcid.org/0000-0002-8536-350X</orcidid><orcidid>https://orcid.org/0000-0003-2997-6712</orcidid><orcidid>https://orcid.org/0000-0003-0040-3638</orcidid><orcidid>https://orcid.org/0000-0003-4382-7799</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics bacterial Cystic fibrosis donor‐derived Extubation Infections lung transplant Lung transplantation Lung transplants Lungs pneumonia Transplants |
| title | Effectiveness of short vs long‐course perioperative antibiotics in lung transplant recipients with donor positive respiratory cultures |
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