Persistence of Maternal Anti-Rotavirus Immunoglobulin G in the Post–Rotavirus Vaccine Era

Abstract To assess whether titers of anti-rotavirus immunoglobulin G persist during the post–rotavirus vaccine era, the Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) Cohort analyzed serum samples collected from Cincinnati-area mothers and young infants in 2017–2018. Rotavirus-specific antibodies continue to be transferred from US mothers to their offspring in the post–rotavirus vaccine era, despite dramatic decreases in childhood rotavirus gastroenteritis. The PREVAIL Cohort of US mothers and their offspring found that US infants may continue to be protected against rotavirus gastroenteritis by maternally transferred, naturally acquired passive immunity, more than a decade after implementation of the US rotavirus vaccination program.