Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation

The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of spp. in both planktonic and biofilm form. The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. β-lap showed antifungal activity against resistant strains of spp. in planktonic form. In addition, β-lap decreased the viability of mature biofilms and inhibited the formation of biofilms . β-lap showed antifungal activity against spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.