Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy

This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2020-12, Vol.324 (22), p.2259-2260
Hauptverfasser:	Agarwal, Anubha, Yancy, Clyde W, Huffman, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Angiotensin Angiotensin Receptor Antagonists - administration & dosage Congestive heart failure Drug Combinations Ejection fraction Heart failure Heart Failure - drug therapy Heart Failure - physiopathology Humans Inhibitors Medication Adherence Mineralocorticoid Receptor Antagonists - administration & dosage Practice Guidelines as Topic Renin Sodium-glucose cotransporter Sodium-Glucose Transporter 2 Inhibitors - administration & dosage Stroke Volume
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Beschreibung
Zusammenfassung:	This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients.
ISSN:	0098-7484 1538-3598
DOI:	10.1001/jama.2020.21395