Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons

There is a growing interest in using targeted protein degradation as a therapeutic modality in view of its potential to expand the druggable proteome. One avenue to using this modality is via molecular glue based Cereblon E3 Ligase Modulating Drug compounds. Here, we report the identification of the...

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Veröffentlicht in:	ACS chemical biology 2020-12, Vol.15 (12), p.3149-3158
Hauptverfasser:	Matyskiela, Mary E, Zhu, Jinyi, Baughman, Joshua M, Clayton, Thomas, Slade, Michelle, Wong, Hon Kit, Danga, Kristina, Zheng, Xinde, Labow, Mark, LeBrun, Laurie, Lu, Gang, Chamberlain, Philip P, Thompson, Joel W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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