The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo

T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in th...

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Veröffentlicht in:Scandinavian journal of immunology 2021-04, Vol.93 (4), p.e13000-e13000
Hauptverfasser: Aghamajidi, Azin, Raoufi, Ehsan, Parsamanesh, Gilda, Jalili, Ahmad, Salehi-Shadkami, Mohammad, Mehrali, Marjan, Mohsenzadegan, Monireh
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Sprache:eng
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Zusammenfassung:T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.13000