The Trinity of SPRTN Protease Regulation

The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layer...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2021-01, Vol.46 (1), p.2-4
Hauptverfasser:	Ruggiano, Annamaria, Ramadan, Kristijan
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer DNA-Binding Proteins - metabolism DNA–protein crosslinks genomic instability Humans SPRTN protease
Online-Zugang:	Volltext
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