The Trinity of SPRTN Protease Regulation

The Trinity of SPRTN Protease Regulation

The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layer...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2021-01, Vol.46 (1), p.2-4
Hauptverfasser: Ruggiano, Annamaria, Ramadan, Kristijan
Format: Artikel
Sprache:eng
Schlagworte:
cancer
DNA-Binding Proteins - metabolism
DNA–protein crosslinks
genomic instability
Humans
SPRTN protease
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Zusammenfassung:The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA–protein crosslinks.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2020.10.007