Comparative genomics of Sporothrix species and identification of putative pathogenic-gene determinants

To understand the phylogenomics, pathogenic/virulence-associated genes and genomic evolution of pathogenic species. We performed comparative genome analysis of species using tools and in-house scripts. We predicted genes and repeats, compared genomes based on synteny, identified orthologous clusters, assessed genes family expansion/contraction, predicted secretory proteins and finally searched for similar sequences from various databases. The phylogenomics revealed that species are closely related to species. The gene family evolutionary analysis revealed the expansion of genes related to virulence (CFEM domain, iron acquisition genes, lysin motif domain), stress response (Su[var]3-9, Enhancer-of-zeste and Trithorax domain and Domain of unknown function 1996), proteases (aspartic protease, x-pro dipeptidyl-peptidase), cell wall composition associated genes (chitin deacetylase, chitinase) and transporters (major facilitator superfamily transporter, oligo-peptide transporter family) in species. The present study documents the putative pathogenic/virulence-associated genes in the species.