Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution

Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution

Villages in Niger were randomly assigned to offer azithromycin or placebo to children 1 to 59 months of age every 6 months for 4 years. Stool samples collected at 36 and 48 months showed that antibiotic resistance was more common among children living in villages that received azithromycin than amon...

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Veröffentlicht in:The New England journal of medicine 2020-11, Vol.383 (20), p.1941-1950
Hauptverfasser: Doan, Thuy, Worden, Lee, Hinterwirth, Armin, Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Zhong, Lina, Chen, Cindi, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Chow, Eric D, Porco, Travis C, Lipsitch, Marc, Keenan, Jeremy D, Lietman, Thomas M
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotic resistance
Antibiotics
Antimicrobial resistance
Azithromycin
Child mortality
Children
Deoxyribonucleic acid
DNA
Drug resistance
Genetic testing
Genomes
Intervention
Rectum
Streptococcus infections
β-Lactam antibiotics
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Zusammenfassung:Villages in Niger were randomly assigned to offer azithromycin or placebo to children 1 to 59 months of age every 6 months for 4 years. Stool samples collected at 36 and 48 months showed that antibiotic resistance was more common among children living in villages that received azithromycin than among children living in villages that received placebo.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2002606