Utilization of Unsymmetric Diaryliodonium Salts in α‐Arylation of α‐Fluoroacetoacetamides

The use of unsymmetric diaryliodonium salts as a versatile class of arylating agents has been demonstrated by developing a novel strategy to quickly access α‐arylated α‐fluoroacetoacetamides. The protocol provides a convenient metal‐free method for the α‐arylation of a diverse class of fluorinated acetoacetamides, and the products are obtained in good yields. The strategy, upon use of electron‐deficient diaryliodonium salts as an arylating agent, provides α‐fluoroacetamides through a spontaneous arylation/deacylation cascade. The use of unsymmetric diaryliodonium salts as a versatile class of arylating agents has been demonstrated by developing a novel strategy to quickly access α‐arylated α‐fluoroacetoacetamides.