The cross-sectional association of frailty with past and current exposure to strong anticholinergic drugs

The cross-sectional association of frailty with past and current exposure to strong anticholinergic drugs

Background Anticholinergic drugs may contribute to frailty by impairing cognitive and physical functions. Strong anticholinergic drugs in particular may have adverse effects among older adults. Objectives Determine the association between frailty and the use of strong anticholinergic drugs among old...

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Veröffentlicht in:Aging clinical and experimental research 2021-08, Vol.33 (8), p.2283-2289
Hauptverfasser: Ruiz, Sergio J., Cevallos, Victor, Baskaran, Dhanya, Mintzer, Michael J., Ruiz, Jorge G.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Anticholinergics
Cognition & reasoning
Cognitive ability
Data warehouses
Drug dosages
Electronic health records
Ethnicity
Frailty
Geriatrics/Gerontology
Medicine
Medicine & Public Health
Mortality
Older people
Original Article
Patients
Pharmacy
Population
Prescription drugs
Primary care
Sociodemographics
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Zusammenfassung:Background Anticholinergic drugs may contribute to frailty by impairing cognitive and physical functions. Strong anticholinergic drugs in particular may have adverse effects among older adults. Objectives Determine the association between frailty and the use of strong anticholinergic drugs among older US Veterans. Methods This is a cross-sectional study of community-dwelling Veterans 65 years and older who had determinations of frailty status. Prescription data for patients using strong anticholinergic medications (never/past/current) was obtained via electronic health records. A 31-item VA Frailty Index (VA-FI) was generated at the time of the assessment. We dichotomized the groups into non-frail (FI =  
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-020-01742-6