Optimising molecular rotors to AIE fluorophores for mitochondria uptake and retention
Molecular rotors exhibit fluorescence enhancement in a confined environment and thus have been used extensively in biological imaging. However, many molecular rotors suffer from small Stokes shift and self-aggregation caused quenching. In this work, we have synthesised a series of red emissive molec...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (94), p.14853-14856 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Molecular rotors exhibit fluorescence enhancement in a confined environment and thus have been used extensively in biological imaging. However, many molecular rotors suffer from small Stokes shift and self-aggregation caused quenching. In this work, we have synthesised a series of red emissive molecular rotors based on cationic α-cyanostilbene. Profoundly enhanced aggregation-induced emission (AIE) properties and greatly widened Stokes shifts can be achieved by molecular engineering. With specificity to stain mitochondria, we demonstrate a simple approach to achieve cell uptake and retention upon tuning the pyridinium substituent of the dyes.
AIE-active molecular rotors for mitochondria imaging with improved uptake and retention in both live and fixed cells. |
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ISSN: | 1359-7345 1364-548X 1364-548X |
DOI: | 10.1039/d0cc06411d |