Effects of the age/rage axis in the platelet activation

Platelet activity is essential in cardiovascular diseases. Therefore our objective was to evaluate the main effects of activating RAGE in platelets which are still unknown. A search for RAGE expression in different databases showed poor or a nonexistent presence in platelets. We confirmed the expres...

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Veröffentlicht in:	International journal of biological macromolecules 2021-01, Vol.166, p.1149-1161
Hauptverfasser:	Recabarren-Leiva, D., Burgos, C.F., Hernández, B., Garcïa-García, F.J., Castro, R.I., Guzman, L., Fuentes, E., Palomo, I., Alarcón, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced glycation end products Aged Blood Platelets - metabolism Cardiovascular disease Computer Simulation Glycation End Products, Advanced - metabolism Humans Methylglyoxal Platelet Platelet Activation Receptor for Advanced Glycation End Products - metabolism Receptor for advanced glycation end products and soluble receptor for advanced glycation end products Serum Albumin, Bovine - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Platelet activity is essential in cardiovascular diseases. Therefore our objective was to evaluate the main effects of activating RAGE in platelets which are still unknown. A search for RAGE expression in different databases showed poor or a nonexistent presence in platelets. We confirmed the expression in platelets and secreted variable of RAGE (sRAGE). Platelets from elderly adults expressed in resting showed 3.2 fold more RAGE from young individuals (p
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2020.10.270