Cd‐Based Metal–Organic Framework for Selective Turn‐On Fluorescent DMSO Residual Sensing

Dimethyl sulfoxide (DMSO) is a universally used solvent in various synthetic reactions, and trace amounts of DMSO residual are often seen on the surface of chemical product. It is difficult to quickly determine whether the residual DMSO is washed completely. This work reports a CdII metal–organic framework (MOF) SXU‐4 which can detect trace amounts of DMSO in various solvents. Fluorescence experiments reveal its turn‐on fluorescence effect toward DMSO with high selectivity and sensitivity, indicating that it can be used as an effective luminescent probe for rapid chemical product purity detection by testing the washing solution. Crystallographically characterized DMSO loaded SXU‐4 (DMSO@SXU‐4), in combination with computational results uncover that the enhanced DMSO–MOF conjugation through multiple DMSO–MOF supramolecule interactions and charge rearrangement are the main causes of fluorescence intensification. Cd‐based MOF SXU‐4 can selectively and sensitively detect trace amount of DMSO in various solvents through a turn‐on based luminescence mechanism. It can be used as luminescent probe for rapid DMSO residual detection.