Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances
The current study examined the stability of several antidoping prohibited substances analytes in urine after 15‐min exposure to UV‐C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV‐2. T...
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| Veröffentlicht in: | Drug testing and analysis 2021-02, Vol.13 (2), p.460-465 |
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| creator | Voss, Sven Abushreeda, Wadha Vonaparti, Ariadni Al‐Wahaibi, Aisha Al‐Sowaidi, Noora Al‐Mohannadi, Ibrahim Mahieddine, Souhila Khelifi, Safa Salama, Sofia Saleh, Amal Al‐Mohannadi, Maryam El‐Saftawy, Wesal Al‐Hamad, Khalifa Nofal, Ahmad Dbes, Najib Aguilera, Rodrigo Al Maadheed, Mohammed Georgakopoulos, Costas |
| description | The current study examined the stability of several antidoping prohibited substances analytes in urine after 15‐min exposure to UV‐C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV‐2. The analytes small molecules Phase I and Phase II metabolites and peptides, in total 444, endogenous, internal standards, and prohibited substances, pH, and specific gravity in urine were studied. The accredited analytical methods were used by Anti‐Doping Laboratory Qatar for the comparison of data of the same urine samples analyzed with and without UV‐C exposure. In the study conditions, no problems of stability were detected in the substances spiked in the urine samples exposed in the UV‐C irradiation.
Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances studied in samples with and without irradiation. The UV‐C irradiation is degrading DNA/RNA and coronaviruses. The biosafety Level 2 cabinet use has been recommended by WADA. |
| doi_str_mv | 10.1002/dta.2954 |
| format | Article |
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Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances studied in samples with and without irradiation. The UV‐C irradiation is degrading DNA/RNA and coronaviruses. The biosafety Level 2 cabinet use has been recommended by WADA.</description><identifier>ISSN: 1942-7603</identifier><identifier>EISSN: 1942-7611</identifier><identifier>DOI: 10.1002/dta.2954</identifier><identifier>PMID: 33119942</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Anabolic Agents - urine ; antidoping analysis ; Biosafety Level 2 ; Containment of Biohazards - methods ; Doping in Sports ; Drug testing ; Drugs & sports ; Humans ; stability ; Substance Abuse Detection - methods ; Ultraviolet Rays ; Urinalysis - methods ; Urine ; UV‐C light</subject><ispartof>Drug testing and analysis, 2021-02, Vol.13 (2), p.460-465</ispartof><rights>2020 John Wiley & Sons, Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3494-6929e556cebee0ba1b40eba7dadb1aab8741aec026a41e1970356ac5308dfda73</citedby><cites>FETCH-LOGICAL-c3494-6929e556cebee0ba1b40eba7dadb1aab8741aec026a41e1970356ac5308dfda73</cites><orcidid>0000-0001-5517-0128 ; 0000-0001-5744-1243</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdta.2954$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdta.2954$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33119942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voss, Sven</creatorcontrib><creatorcontrib>Abushreeda, Wadha</creatorcontrib><creatorcontrib>Vonaparti, Ariadni</creatorcontrib><creatorcontrib>Al‐Wahaibi, Aisha</creatorcontrib><creatorcontrib>Al‐Sowaidi, Noora</creatorcontrib><creatorcontrib>Al‐Mohannadi, Ibrahim</creatorcontrib><creatorcontrib>Mahieddine, Souhila</creatorcontrib><creatorcontrib>Khelifi, Safa</creatorcontrib><creatorcontrib>Salama, Sofia</creatorcontrib><creatorcontrib>Saleh, Amal</creatorcontrib><creatorcontrib>Al‐Mohannadi, Maryam</creatorcontrib><creatorcontrib>El‐Saftawy, Wesal</creatorcontrib><creatorcontrib>Al‐Hamad, Khalifa</creatorcontrib><creatorcontrib>Nofal, Ahmad</creatorcontrib><creatorcontrib>Dbes, Najib</creatorcontrib><creatorcontrib>Aguilera, Rodrigo</creatorcontrib><creatorcontrib>Al Maadheed, Mohammed</creatorcontrib><creatorcontrib>Georgakopoulos, Costas</creatorcontrib><title>Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances</title><title>Drug testing and analysis</title><addtitle>Drug Test Anal</addtitle><description>The current study examined the stability of several antidoping prohibited substances analytes in urine after 15‐min exposure to UV‐C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV‐2. The analytes small molecules Phase I and Phase II metabolites and peptides, in total 444, endogenous, internal standards, and prohibited substances, pH, and specific gravity in urine were studied. The accredited analytical methods were used by Anti‐Doping Laboratory Qatar for the comparison of data of the same urine samples analyzed with and without UV‐C exposure. In the study conditions, no problems of stability were detected in the substances spiked in the urine samples exposed in the UV‐C irradiation.
Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances studied in samples with and without irradiation. The UV‐C irradiation is degrading DNA/RNA and coronaviruses. The biosafety Level 2 cabinet use has been recommended by WADA.</description><subject>Anabolic Agents - urine</subject><subject>antidoping analysis</subject><subject>Biosafety Level 2</subject><subject>Containment of Biohazards - methods</subject><subject>Doping in Sports</subject><subject>Drug testing</subject><subject>Drugs & sports</subject><subject>Humans</subject><subject>stability</subject><subject>Substance Abuse Detection - methods</subject><subject>Ultraviolet Rays</subject><subject>Urinalysis - methods</subject><subject>Urine</subject><subject>UV‐C light</subject><issn>1942-7603</issn><issn>1942-7611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhy0Eon9A4gmQJS69pNiOk6yPZUsBaSUuLddobE-6rpw42E5hbzwCR56PJ8FLS5GQuNgjz-dvRvoR8oKzU86YeG0znArVyEfkkCspqq7l_PFDzeoDcpTSDWOtFHXzlBzUNeeqNA_JjzcuJBgw7-gGb9FTQQ1oN2GmV59-fvu-pt5dbzPFr3NIS0QaBprmEHOiMGVnw-yma7pdRpjoEss_mmCcPSZqQzmmkCkMA5pM87b0cnF7V4btNejLO1o6x7B12u3LtOjCTAbTM_JkAJ_w-f19TK4u3l6u31ebj-8-rM82lamlklWrhMKmaQ1qRKaBa8lQQ2fBag6gV53kgIaJFiRHrjpWNy2YpmYrO1jo6mNycuctW3xeMOV-dMmg9zBhWFIvZNNKrrhqC_rqH_QmLHEq2xVq1TWdkFL-FZoYUoo49HN0I8Rdz1m_T6svafX7tAr68l646BHtA_gnngJUd8AX53H3X1F_fnn2W_gLM3yhog</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Voss, Sven</creator><creator>Abushreeda, Wadha</creator><creator>Vonaparti, Ariadni</creator><creator>Al‐Wahaibi, Aisha</creator><creator>Al‐Sowaidi, Noora</creator><creator>Al‐Mohannadi, Ibrahim</creator><creator>Mahieddine, Souhila</creator><creator>Khelifi, Safa</creator><creator>Salama, Sofia</creator><creator>Saleh, Amal</creator><creator>Al‐Mohannadi, Maryam</creator><creator>El‐Saftawy, Wesal</creator><creator>Al‐Hamad, Khalifa</creator><creator>Nofal, Ahmad</creator><creator>Dbes, Najib</creator><creator>Aguilera, Rodrigo</creator><creator>Al Maadheed, Mohammed</creator><creator>Georgakopoulos, Costas</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5517-0128</orcidid><orcidid>https://orcid.org/0000-0001-5744-1243</orcidid></search><sort><creationdate>202102</creationdate><title>Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances</title><author>Voss, Sven ; Abushreeda, Wadha ; Vonaparti, Ariadni ; Al‐Wahaibi, Aisha ; Al‐Sowaidi, Noora ; Al‐Mohannadi, Ibrahim ; Mahieddine, Souhila ; Khelifi, Safa ; Salama, Sofia ; Saleh, Amal ; Al‐Mohannadi, Maryam ; El‐Saftawy, Wesal ; Al‐Hamad, Khalifa ; Nofal, Ahmad ; Dbes, Najib ; Aguilera, Rodrigo ; Al Maadheed, Mohammed ; Georgakopoulos, Costas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3494-6929e556cebee0ba1b40eba7dadb1aab8741aec026a41e1970356ac5308dfda73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anabolic Agents - urine</topic><topic>antidoping analysis</topic><topic>Biosafety Level 2</topic><topic>Containment of Biohazards - methods</topic><topic>Doping in Sports</topic><topic>Drug testing</topic><topic>Drugs & sports</topic><topic>Humans</topic><topic>stability</topic><topic>Substance Abuse Detection - methods</topic><topic>Ultraviolet Rays</topic><topic>Urinalysis - methods</topic><topic>Urine</topic><topic>UV‐C light</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voss, Sven</creatorcontrib><creatorcontrib>Abushreeda, Wadha</creatorcontrib><creatorcontrib>Vonaparti, Ariadni</creatorcontrib><creatorcontrib>Al‐Wahaibi, Aisha</creatorcontrib><creatorcontrib>Al‐Sowaidi, Noora</creatorcontrib><creatorcontrib>Al‐Mohannadi, Ibrahim</creatorcontrib><creatorcontrib>Mahieddine, Souhila</creatorcontrib><creatorcontrib>Khelifi, Safa</creatorcontrib><creatorcontrib>Salama, Sofia</creatorcontrib><creatorcontrib>Saleh, Amal</creatorcontrib><creatorcontrib>Al‐Mohannadi, Maryam</creatorcontrib><creatorcontrib>El‐Saftawy, Wesal</creatorcontrib><creatorcontrib>Al‐Hamad, Khalifa</creatorcontrib><creatorcontrib>Nofal, Ahmad</creatorcontrib><creatorcontrib>Dbes, Najib</creatorcontrib><creatorcontrib>Aguilera, Rodrigo</creatorcontrib><creatorcontrib>Al Maadheed, Mohammed</creatorcontrib><creatorcontrib>Georgakopoulos, Costas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Drug testing and analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voss, Sven</au><au>Abushreeda, Wadha</au><au>Vonaparti, Ariadni</au><au>Al‐Wahaibi, Aisha</au><au>Al‐Sowaidi, Noora</au><au>Al‐Mohannadi, Ibrahim</au><au>Mahieddine, Souhila</au><au>Khelifi, Safa</au><au>Salama, Sofia</au><au>Saleh, Amal</au><au>Al‐Mohannadi, Maryam</au><au>El‐Saftawy, Wesal</au><au>Al‐Hamad, Khalifa</au><au>Nofal, Ahmad</au><au>Dbes, Najib</au><au>Aguilera, Rodrigo</au><au>Al Maadheed, Mohammed</au><au>Georgakopoulos, Costas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances</atitle><jtitle>Drug testing and analysis</jtitle><addtitle>Drug Test Anal</addtitle><date>2021-02</date><risdate>2021</risdate><volume>13</volume><issue>2</issue><spage>460</spage><epage>465</epage><pages>460-465</pages><issn>1942-7603</issn><eissn>1942-7611</eissn><abstract>The current study examined the stability of several antidoping prohibited substances analytes in urine after 15‐min exposure to UV‐C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV‐2. The analytes small molecules Phase I and Phase II metabolites and peptides, in total 444, endogenous, internal standards, and prohibited substances, pH, and specific gravity in urine were studied. The accredited analytical methods were used by Anti‐Doping Laboratory Qatar for the comparison of data of the same urine samples analyzed with and without UV‐C exposure. In the study conditions, no problems of stability were detected in the substances spiked in the urine samples exposed in the UV‐C irradiation.
Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances studied in samples with and without irradiation. The UV‐C irradiation is degrading DNA/RNA and coronaviruses. The biosafety Level 2 cabinet use has been recommended by WADA.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33119942</pmid><doi>10.1002/dta.2954</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5517-0128</orcidid><orcidid>https://orcid.org/0000-0001-5744-1243</orcidid></addata></record> |
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| ispartof | Drug testing and analysis, 2021-02, Vol.13 (2), p.460-465 |
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| subjects | Anabolic Agents - urine antidoping analysis Biosafety Level 2 Containment of Biohazards - methods Doping in Sports Drug testing Drugs & sports Humans stability Substance Abuse Detection - methods Ultraviolet Rays Urinalysis - methods Urine UV‐C light |
| title | Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances |
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