A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins

Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) protei...

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Veröffentlicht in:	FEBS letters 2020-12, Vol.594 (23), p.3986-4000
Hauptverfasser:	Geisler, Markus, Hegedűs, Tamás
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters ABCB Animals ATP Binding Cassette Transporter, Subfamily B - chemistry ATP Binding Cassette Transporter, Subfamily B - metabolism ATP-Binding Cassette Sub-Family B Member 4 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - classification ATP-Binding Cassette Transporters - metabolism Biological Transport CFTR chaperon Cystic Fibrosis Transmembrane Conductance Regulator - biosynthesis Cystic Fibrosis Transmembrane Conductance Regulator - metabolism FKBP FKBP38 HSP90 HSP90 Heat-Shock Proteins - metabolism Humans Immunophilins - metabolism Models, Molecular PPIase Proline - metabolism Tacrolimus Binding Protein 1A - metabolism Tacrolimus Binding Proteins - metabolism TWD1
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Zusammenfassung:	Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBP‐ABC modules in plants and mammals. We dissect a PPIase‐ and HSP90‐dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis–trans isomerization of X‐prolyl bonds.
ISSN:	0014-5793 1873-3468
DOI:	10.1002/1873-3468.13983