AlignmentViewer: Sequence Analysis of Large Protein Families [version 1; peer review: 1 approved, 1 approved with reservations]

AlignmentViewer is a web-based tool used to view and analyze multiple sequence alignments of protein families. The particular strengths of AlignmentViewer include flexible visualization at different scales as well as analysis of conservation patterns and of the distribution of proteins in sequence space. The tool is directly accessible in web browsers without the need for software installation. It can handle protein families with tens of thousands of sequences and is particularly suitable for evolutionary coupling analysis, e.g. via EVcouplings.org. AlignmentViewer is open source software under the MIT license. The viewer is available at http://alignmentviewer.org and the source code, documentation and issue tracking are available at https://github.com/sanderlab/alignmentviewer